Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Anorexia Nervosa Genetics Initiative; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Hunna J. Watson; Zeynep Yilmaz; Laura M. Thornton; Christopher Hübel; Jonathan R.I. Coleman; Héléna A. Gaspar; Julien Bryois; Anke Hinney; Virpi M. Leppä; Manuel Mattheisen; Sarah E. Medland; Stephan Ripke; Shuyang Yao; Paola Giusti-Rodríguez; Ken B. Hanscombe; Kirstin L. Purves; Roger A.H. Adan; Lars Alfredsson; Tetsuya Ando; Ole A. Andreassen; Jessica H. Baker; Wade H. Berrettini; Ilka Boehm; Claudette Boni; Vesna Boraska Perica; Katharina Buehren; Roland Burghardt; Matteo Cassina; Sven Cichon; Maurizio Clementi; Roger D. Cone; Philippe Courtet; Scott Crow; James J. Crowley; Unna N. Danner; Oliver S.P. Davis; Martina de Zwaan; George Dedoussis; Daniela Degortes; Janiece E. DeSocio; Danielle M. Dick; Dimitris Dikeos; Christian Dina; Monika Dmitrzak-Weglarz; Elisa Docampo; Laramie E. Duncan; Karin Egberts; Stefan Ehrlich; Geòrgia Escaramís; Sandro Sorbi

doi:10.1038/s41588-019-0439-2

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Anorexia Nervosa Genetics Initiative, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Hunna J. Watson, Zeynep Yilmaz, Laura M. Thornton, Christopher Hübel, Jonathan R.I. Coleman, Héléna A. Gaspar, Julien Bryois, Anke Hinney, Virpi M. Leppä, Manuel Mattheisen, Sarah E. Medland, Stephan Ripke, Shuyang Yao, Paola Giusti-Rodríguez, Ken B. Hanscombe, Kirstin L. Purves, Roger A.H. Adan, Lars AlfredssonTetsuya Ando, Ole A. Andreassen, Jessica H. Baker, Wade H. Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D. Cone, Philippe Courtet, Scott Crow, James J. Crowley, Unna N. Danner, Oliver S.P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie E. Duncan, Karin Egberts, Stefan Ehrlich, Geòrgia Escaramís, Sandro Sorbi

Research output: Contribution to journal › Letter › peer-review

Abstract

Genome-wide analyses identify eight independent loci associated with anorexia nervosa. Genetic correlations implicate both psychiatric and metabolic components in the etiology of this disorder, even after adjusting for the effects of common variants associated with body mass index.

Original language	English
Journal	Nature Genetics
DOIs	https://doi.org/10.1038/s41588-019-0439-2
Publication status	Published - Aug 1 2019

ASJC Scopus subject areas

Genetics

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Anorexia Nervosa Genetics Initiative, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Watson, H. J., Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A., Bryois, J., Hinney, A., Leppä, V. M., Mattheisen, M., Medland, S. E., Ripke, S., Yao, S., Giusti-Rodríguez, P., Hanscombe, K. B., Purves, K. L., Adan, R. A. H., ... Sorbi, S. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics. https://doi.org/10.1038/s41588-019-0439-2

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. / Anorexia Nervosa Genetics Initiative; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Watson, Hunna J.; Yilmaz, Zeynep; Thornton, Laura M.; Hübel, Christopher; Coleman, Jonathan R.I.; Gaspar, Héléna A.; Bryois, Julien; Hinney, Anke; Leppä, Virpi M.; Mattheisen, Manuel; Medland, Sarah E.; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola; Hanscombe, Ken B.; Purves, Kirstin L.; Adan, Roger A.H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A.; Baker, Jessica H.; Berrettini, Wade H.; Boehm, Ilka; Boni, Claudette; Perica, Vesna Boraska; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Cone, Roger D.; Courtet, Philippe; Crow, Scott; Crowley, James J.; Danner, Unna N.; Davis, Oliver S.P.; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E.; Dick, Danielle M.; Dikeos, Dimitris; Dina, Christian; Dmitrzak-Weglarz, Monika; Docampo, Elisa; Duncan, Laramie E.; Egberts, Karin; Ehrlich, Stefan; Escaramís, Geòrgia; Sorbi, Sandro.

In: Nature Genetics, 01.08.2019.

Research output: Contribution to journal › Letter › peer-review

Anorexia Nervosa Genetics Initiative, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Watson, HJ, Yilmaz, Z, Thornton, LM, Hübel, C, Coleman, JRI, Gaspar, HA, Bryois, J, Hinney, A, Leppä, VM, Mattheisen, M, Medland, SE, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, KB, Purves, KL, Adan, RAH, Alfredsson, L, Ando, T, Andreassen, OA, Baker, JH, Berrettini, WH, Boehm, I, Boni, C, Perica, VB, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, RD, Courtet, P, Crow, S, Crowley, JJ, Danner, UN, Davis, OSP, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, JE, Dick, DM, Dikeos, D, Dina, C, Dmitrzak-Weglarz, M, Docampo, E, Duncan, LE, Egberts, K, Ehrlich, S, Escaramís, G & Sorbi, S 2019, 'Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa', Nature Genetics. https://doi.org/10.1038/s41588-019-0439-2

Anorexia Nervosa Genetics Initiative ; Eating Disorders Working Group of the Psychiatric Genomics Consortium ; Watson, Hunna J. ; Yilmaz, Zeynep ; Thornton, Laura M. ; Hübel, Christopher ; Coleman, Jonathan R.I. ; Gaspar, Héléna A. ; Bryois, Julien ; Hinney, Anke ; Leppä, Virpi M. ; Mattheisen, Manuel ; Medland, Sarah E. ; Ripke, Stephan ; Yao, Shuyang ; Giusti-Rodríguez, Paola ; Hanscombe, Ken B. ; Purves, Kirstin L. ; Adan, Roger A.H. ; Alfredsson, Lars ; Ando, Tetsuya ; Andreassen, Ole A. ; Baker, Jessica H. ; Berrettini, Wade H. ; Boehm, Ilka ; Boni, Claudette ; Perica, Vesna Boraska ; Buehren, Katharina ; Burghardt, Roland ; Cassina, Matteo ; Cichon, Sven ; Clementi, Maurizio ; Cone, Roger D. ; Courtet, Philippe ; Crow, Scott ; Crowley, James J. ; Danner, Unna N. ; Davis, Oliver S.P. ; de Zwaan, Martina ; Dedoussis, George ; Degortes, Daniela ; DeSocio, Janiece E. ; Dick, Danielle M. ; Dikeos, Dimitris ; Dina, Christian ; Dmitrzak-Weglarz, Monika ; Docampo, Elisa ; Duncan, Laramie E. ; Egberts, Karin ; Ehrlich, Stefan ; Escaramís, Geòrgia ; Sorbi, Sandro. / Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. In: Nature Genetics. 2019.

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title = "Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa",

abstract = "Genome-wide analyses identify eight independent loci associated with anorexia nervosa. Genetic correlations implicate both psychiatric and metabolic components in the etiology of this disorder, even after adjusting for the effects of common variants associated with body mass index.",

author = "{Anorexia Nervosa Genetics Initiative} and {Eating Disorders Working Group of the Psychiatric Genomics Consortium} and Watson, {Hunna J.} and Zeynep Yilmaz and Thornton, {Laura M.} and Christopher H{\"u}bel and Coleman, {Jonathan R.I.} and Gaspar, {H{\'e}l{\'e}na A.} and Julien Bryois and Anke Hinney and Lepp{\"a}, {Virpi M.} and Manuel Mattheisen and Medland, {Sarah E.} and Stephan Ripke and Shuyang Yao and Paola Giusti-Rodr{\'i}guez and Hanscombe, {Ken B.} and Purves, {Kirstin L.} and Adan, {Roger A.H.} and Lars Alfredsson and Tetsuya Ando and Andreassen, {Ole A.} and Baker, {Jessica H.} and Berrettini, {Wade H.} and Ilka Boehm and Claudette Boni and Perica, {Vesna Boraska} and Katharina Buehren and Roland Burghardt and Matteo Cassina and Sven Cichon and Maurizio Clementi and Cone, {Roger D.} and Philippe Courtet and Scott Crow and Crowley, {James J.} and Danner, {Unna N.} and Davis, {Oliver S.P.} and {de Zwaan}, Martina and George Dedoussis and Daniela Degortes and DeSocio, {Janiece E.} and Dick, {Danielle M.} and Dimitris Dikeos and Christian Dina and Monika Dmitrzak-Weglarz and Elisa Docampo and Duncan, {Laramie E.} and Karin Egberts and Stefan Ehrlich and Ge{\`o}rgia Escaram{\'i}s and Sandro Sorbi",

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AU - Yilmaz, Zeynep

AU - Thornton, Laura M.

AU - Hübel, Christopher

AU - Coleman, Jonathan R.I.

AU - Gaspar, Héléna A.

AU - Bryois, Julien

AU - Hinney, Anke

AU - Leppä, Virpi M.

AU - Mattheisen, Manuel

AU - Medland, Sarah E.

AU - Ripke, Stephan

AU - Yao, Shuyang

AU - Giusti-Rodríguez, Paola

AU - Hanscombe, Ken B.

AU - Purves, Kirstin L.

AU - Adan, Roger A.H.

AU - Alfredsson, Lars

AU - Ando, Tetsuya

AU - Andreassen, Ole A.

AU - Baker, Jessica H.

AU - Berrettini, Wade H.

AU - Boehm, Ilka

AU - Boni, Claudette

AU - Perica, Vesna Boraska

AU - Buehren, Katharina

AU - Burghardt, Roland

AU - Cassina, Matteo

AU - Cichon, Sven

AU - Clementi, Maurizio

AU - Cone, Roger D.

AU - Courtet, Philippe

AU - Crow, Scott

AU - Crowley, James J.

AU - Danner, Unna N.

AU - Davis, Oliver S.P.

AU - de Zwaan, Martina

AU - Dedoussis, George

AU - Degortes, Daniela

AU - DeSocio, Janiece E.

AU - Dick, Danielle M.

AU - Dikeos, Dimitris

AU - Dina, Christian

AU - Dmitrzak-Weglarz, Monika

AU - Docampo, Elisa

AU - Duncan, Laramie E.

AU - Egberts, Karin

AU - Ehrlich, Stefan

AU - Escaramís, Geòrgia

AU - Sorbi, Sandro

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AB - Genome-wide analyses identify eight independent loci associated with anorexia nervosa. Genetic correlations implicate both psychiatric and metabolic components in the etiology of this disorder, even after adjusting for the effects of common variants associated with body mass index.

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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

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