Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion

Francesco Forconi, Andrea Rinaldi, Ivo Kwee, Elisa Sozzi, Donatella Raspadori, Paola M V Rancoita, Marta Scandurra, Davide Rossi, Clara Deambrogi, Daniela Capello, Emanuele Zucca, Daniela Marconi, Riccardo Bomben, Valter Gattei, Francesco Lauria, Gianluca Gaidano, Francesco Bertoni

Research output: Contribution to journalArticle

Abstract

Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P <0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.

Original languageEnglish
Pages (from-to)532-536
Number of pages5
JournalBritish Journal of Haematology
Volume143
Issue number4
DOIs
Publication statusPublished - Nov 2008

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Keywords

  • 17p13 deletion
  • 250K Affymetrix
  • Chronic lymphocytic leukaemia
  • Genome-wide DNA profile
  • Single nucleotide polymporphysms
  • TP53

ASJC Scopus subject areas

  • Hematology

Cite this

Forconi, F., Rinaldi, A., Kwee, I., Sozzi, E., Raspadori, D., Rancoita, P. M. V., Scandurra, M., Rossi, D., Deambrogi, C., Capello, D., Zucca, E., Marconi, D., Bomben, R., Gattei, V., Lauria, F., Gaidano, G., & Bertoni, F. (2008). Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion. British Journal of Haematology, 143(4), 532-536. https://doi.org/10.1111/j.1365-2141.2008.07373.x