Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Xiangdong Liu, Pietro Invernizzi, Yue Lu, Roman Kosoy, Yan Lu, Ilaria Bianchi, Mauro Podda, Chun Xu, Gang Xie, Fabio MacCiardi, Carlo Selmi, Sara Lupoli, Russell Shigeta, Michael Ransom, Ana Lleo, Annette T. Lee, Andrew L. Mason, Robert P. Myers, Kevork M. Peltekian, Cameron N. GhentFrancesca Bernuzzi, Massimo Zuin, Floriano Rosina, Elisabetta Borghesio, Annarosa Floreani, Roberta Lazzari, Grazia Niro, Angelo Andriulli, Luigi Muratori, Paolo Muratori, Piero L. Almasio, Pietro Andreone, Marzia Margotti, Maurizia Brunetto, Barbara Coco, Domenico Alvaro, Maria C. Bragazzi, Fabio Marra, Alessandro Pisano, Cristina Rigamonti, Massimo Colombo, Marco Marzioni, Antonio Benedetti, Luca Fabris, Mario Strazzabosco, Piero Portincasa, Vincenzo O. Palmieri, Claudio Tiribelli, Lory Croce, Savino Bruno, Sonia Rossi, Maria Vinci, Cleofe Prisco, Alberto Mattalia, Pierluigi Toniutto, Antonio Picciotto, Andrea Galli, Carlo Ferrari, Silvia Colombo, Giovanni Casella, Lorenzo Morini, Nicola Caporaso, Agostino Colli, Giancarlo Spinzi, Renzo Montanari, Peter K. Gregersen, E. Jenny Heathcote, Gideon M. Hirschfield, Katherine A. Siminovitch, Christopher I. Amos, M. Eric Gershwin, Michael F. Seldin

Research output: Contribution to journalArticle

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10-11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10 -10, OR = 1.63) and 17q12-21 (P = 1.7 × 10-10, OR = 1.38).

Original languageEnglish
Pages (from-to)658-660
Number of pages3
JournalNature Genetics
Volume42
Issue number8
DOIs
Publication statusPublished - Aug 2010

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ASJC Scopus subject areas

  • Genetics

Cite this

Liu, X., Invernizzi, P., Lu, Y., Kosoy, R., Lu, Y., Bianchi, I., Podda, M., Xu, C., Xie, G., MacCiardi, F., Selmi, C., Lupoli, S., Shigeta, R., Ransom, M., Lleo, A., Lee, A. T., Mason, A. L., Myers, R. P., Peltekian, K. M., ... Seldin, M. F. (2010). Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nature Genetics, 42(8), 658-660. https://doi.org/10.1038/ng.627