Genomewide association study of severe covid-19 with respiratory failure

The Severe Covid-19 GWAS Group, David Ellinghaus, Frauke Degenhardt, Luis Bujanda, Maria Buti, Agustín Albillos, Pietro Invernizzi, Javier Fernández, Daniele Prati, Guido Baselli, Rosanna Asselta, Marit M. Grimsrud, Chiara Milani, Alberto Zanella, Alessandra Bandera, Alessandro Protti, Alessio Aghemo, Ana Lleo, Andrea Gori, Anna LatianoAnna Ludovica Fracanzani, Antonio Pesenti, Antonio Voza, Cinzia Paccapelo, Claudio Angelini, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Francesco Blasi, Giacomo Grasselli, Giorgio Costantino, Giulia Cardamone, Leonardo Terranova, Luigi Santoro, Luigia Scudeller, Maria Carrabba, Maurizio Cecconi, Michele Ciccarelli, Monica Miozzo, Nicola Montano, Orazio Palmieri, Paoletta Preatoni, Paolo Tentorio, Salvatore Badalamenti, Serena Pelusi, Stefano Aliberti, Valter Monzani, Valeria Rimoldi, Silvano Bosari, Stefano Duga, Luca Valenti

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. METHODS We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case–control panels. RESULTS We detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P
Original languageEnglish
Pages (from-to)1522-1534
Number of pages13
JournalNew Engl. J. Med.
Volume383
Issue number16
DOIs
Publication statusPublished - Oct 15 2020

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