Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma

Ivo Kwee, Daniela Capello, Andrea Rinaldi, Paola M V Rancoita, Govind Bhagat, Tim C. Greiner, Michele Spina, Annunziata Gloghini, Wing C. Chan, Marco Paulli, Emanuele Zucca, Umberto Tirelli, Antonino Carbone, Gianluca Gaidano, Francesco Bertoni

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to evaluate the prognostic impact of genomic regions in a series of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphomas (HIV-DLBCLs) and post-transplant DLBCLs (PT-DLBCLs) analyzed by genome-wide DNA profiling. Minimal common regions (MCRs) were estimated on genomic profiles obtained using Affymetrix Human Mapping 250k Nsp I arrays and tested for their impact on clinical outcome by univariate analysis on 36 PT-DLBCLs, 19 HIV-DLBCLs and, as a control group, 149 DLBCLs arising in immunocompetent individuals (IC-DLBCLs). PT-DLBCL and HIV-DLBCL presented a similar outcome. Immunodeficiency-related DLBCL (ID-DLBCL) had a worse overall survival (OS) than IC-DLBCL. Seven MCRs showed a statistical impact on OS in PT-DLBCL and four in HIV-DLBCL. Among these, the presence of gains at 1q or at 18q defined a group of patients with PT-DLBCL with a very poor outcome (p <0.0001). The presence of del(3p14.2) or of + 2p23.1 identified a group of HIV-DLBCLs with a very poor outcome (p = 0.0072). It was concluded that genomic aberrations affecting outcome differ between ID-DLBCL and IC-DLBCL and are also dependent on the type of acquired immunodeficiency.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalLeukemia and Lymphoma
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Diffuse large B-cell lymphoma
  • FHIT
  • HIV
  • Immunodeficiency
  • Lymphoma
  • Organ transplant
  • Outcome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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