Genomic alterations in rectal tumors and response to neoadjuvant chemoradiotherapy: An exploratory study

Chiara Molinari, Michela Ballardini, Nazario Teodorani, Massimo Giannini, Wainer Zoli, Ermanno Emiliani, Enrico Lucci, Alessandro Passardi, Paola Rosetti, Luca Saragoni, Massimo Guidoboni, Dino Amadori, Daniele Calistri

Research output: Contribution to journalArticle

Abstract

Background: Neoadjuvant chemoradiotherapy is the treatment of choice in advanced rectal cancer, even though there are many patients who will not benefit from it. There are still no effective methods for predicting which patients will respond or not. The present study aimed to define the genomic profile of rectal tumors and to identify alterations that are predictive of response in order to optimize therapeutic strategies.Methods: Forty-eight candidates for neoadjuvant chemoradiotherapy were recruited and their pretherapy biopsies analyzed by array Comparative Genomic Hybridization (aCGH). Pathologic response was evaluated by tumor regression grade.Results: Both Hidden Markov Model and Smoothing approaches identified similar alterations, with a prevalence of DNA gains. Non responsive patients had a different alteration profile from responsive ones, with a higher number of genome changes mainly located on 2q21, 3q29, 7p22-21, 7q21, 7q36, 8q23-24, 10p14-13, 13q12, 13q31-34, 16p13, 17p13-12 and 18q23 chromosomal regions.Conclusions: This exploratory study suggests that an in depth characterization of chromosomal alterations by aCGH would provide useful predictive information on response to neoadjuvant chemoradiotherapy and could help to optimize therapy in rectal cancer patients.The data discussed in this study are available on the NCBI Gene Expression Omnibus [GEO: GSE25885].

Original languageEnglish
Article number161
JournalRadiation Oncology
Volume6
Issue number1
DOIs
Publication statusPublished - Nov 18 2011

Keywords

  • Arraycgh
  • Genomic alterations
  • Neoadjuvant chemoradiotherapy
  • Rectal cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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    Molinari, C., Ballardini, M., Teodorani, N., Giannini, M., Zoli, W., Emiliani, E., Lucci, E., Passardi, A., Rosetti, P., Saragoni, L., Guidoboni, M., Amadori, D., & Calistri, D. (2011). Genomic alterations in rectal tumors and response to neoadjuvant chemoradiotherapy: An exploratory study. Radiation Oncology, 6(1), [161]. https://doi.org/10.1186/1748-717X-6-161