Genomic analysis reveals association of specific SNPs with athletic performance and susceptibility to injuries in professional soccer players

Raffaele La Montagna, Raffaele Canonico, Luigi Alfano, Enrico Bucci, Silvia Boffo, Leopoldo Staiano, Beniamino Fulco, Enrico D'Andrea, Antonio De Nicola, Patrizia Maiorano, Costantino D'Angelo, Andrea Chirico, Alfonso De Nicola, Antonio Giordano

Research output: Contribution to journalArticle

Abstract

The development of specific and individualized training programs is a possible way to improve athletic performance and minimize injuries in professional athletes. The information regarding the sport's physical demands and the athletes’ physical profile have been, so far, considered as exhaustive for the design of effective training programs. However, it is currently emerging that the genetic profile has to be also taken into consideration. By merging medical and genetic data, it is thus possible to identify the athlete's specific attitude to respond to training, diet, and physical stress. In this context, we performed a study in which 30 professional soccer players, subjected to standard sport medical evaluation and practices, were also screened for genetic polymorphism in five key genes (ACTN3, COL5A1, MCT1, VEGF, and HFE). This genetic analysis represents the central point of a multidisciplinary method that can be adopted by elite soccer teams to obtain an improvement in athletic performance and a concomitant reduction of injuries by tailoring training and nutritional programs. The genetic fingerprinting of single athletes led to the identification of two performance-enhancing polymorphisms (ACTN3 18705C>T, VEGF-634C>G) significantly enriched. Moreover, we derived a genetic model based on the gene set analyzed, which was tentatively used to reduce athletes’ predisposition to injuries, by dictating a personalized nutrition and training program. The potential usefulness of this approach is concordant with data showing that this team has been classified as the healthiest and least injured team in Europe while covering the highest distance/match with the highest number of high-intensity actions/match.

Original languageEnglish
JournalJournal of Cellular Physiology
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Athletic Performance
Soccer
Nutrition
Sports
Polymorphism
Athletes
Vascular Endothelial Growth Factor A
Single Nucleotide Polymorphism
Genes
Association reactions
Wounds and Injuries
Education
Merging
DNA Fingerprinting
Genetic Models
Medical Genetics
Genetic Polymorphisms
Diet

Keywords

  • athletic performance
  • genes
  • injuries
  • professional soccer players
  • single-nucleotide polymorphisms

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Genomic analysis reveals association of specific SNPs with athletic performance and susceptibility to injuries in professional soccer players. / La Montagna, Raffaele; Canonico, Raffaele; Alfano, Luigi; Bucci, Enrico; Boffo, Silvia; Staiano, Leopoldo; Fulco, Beniamino; D'Andrea, Enrico; De Nicola, Antonio; Maiorano, Patrizia; D'Angelo, Costantino; Chirico, Andrea; De Nicola, Alfonso; Giordano, Antonio.

In: Journal of Cellular Physiology, 01.01.2019.

Research output: Contribution to journalArticle

La Montagna, R, Canonico, R, Alfano, L, Bucci, E, Boffo, S, Staiano, L, Fulco, B, D'Andrea, E, De Nicola, A, Maiorano, P, D'Angelo, C, Chirico, A, De Nicola, A & Giordano, A 2019, 'Genomic analysis reveals association of specific SNPs with athletic performance and susceptibility to injuries in professional soccer players', Journal of Cellular Physiology. https://doi.org/10.1002/jcp.29118
La Montagna, Raffaele ; Canonico, Raffaele ; Alfano, Luigi ; Bucci, Enrico ; Boffo, Silvia ; Staiano, Leopoldo ; Fulco, Beniamino ; D'Andrea, Enrico ; De Nicola, Antonio ; Maiorano, Patrizia ; D'Angelo, Costantino ; Chirico, Andrea ; De Nicola, Alfonso ; Giordano, Antonio. / Genomic analysis reveals association of specific SNPs with athletic performance and susceptibility to injuries in professional soccer players. In: Journal of Cellular Physiology. 2019.
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