Genomic biomarkers and clinical outcomes of physical activity

Research output: Contribution to journalArticle

Abstract

Clinical and experimental studies in humans provide evidence that moderate physical activity significantly decreases artery oxidative damage to nuclear DNA, DNA-adducts related to age and dyslipedemia, and mitochondrial DNA damage. Maintenance of adequate mitochondrial function is crucial for preventing lipid accumulation and peroxidation occurring in atherosclerosis. Studies performed on human muscle biopsies analyzing gene expression in living humans reveal that physically active subjects improve the expression of genes involved in mitochondrial function and of related microRNAs. The attenuation of oxidative damage to nuclear and mitochondrial DNA by physical activity resulted in beneficial effects due to polymorphisms of glutathione S-transferases genes. Subjects bearing nullGSTM1/T1polymorphisms have poor life expectancy in the case of being sedentary, which was increased 2.6-fold in case they performed physical activity. These findings indicate that the preventive effect of physical activity undergoes interindividual variation affected by genetic polymorphisms.

Original languageEnglish
Pages (from-to)103-114
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume1229
Issue number1
DOIs
Publication statusPublished - Jul 2011

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Keywords

  • DNA damage
  • Gene expression
  • Gene polymorphisms
  • Molecular biomarkers
  • Physical activity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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