Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy

Claudia Alteri, Valeria Cento, Antonio Piralla, Valentino Costabile, Monica Tallarita, Luna Colagrossi, Silvia Renica, Federica Giardina, Federica Novazzi, Stefano Gaiarsa, Elisa Matarazzo, Maria Antonello, Chiara Vismara, Roberto Fumagalli, Oscar Massimiliano Epis, Massimo Puoti, Carlo Federico Perno, Fausto Baldanti

Research output: Contribution to journalArticlepeer-review

Abstract

From February to April 2020, Lombardy (Italy) reported the highest numbers of SARS-CoV-2 cases worldwide. By analyzing 346 whole SARS-CoV-2 genomes, we demonstrate the presence of seven viral lineages in Lombardy, frequently sustained by local transmission chains and at least two likely to have originated in Italy. Six single nucleotide polymorphisms (five of them non-synonymous) characterized the SARS-CoV-2 sequences, none of them affecting N-glycosylation sites. The seven lineages, and the presence of local transmission clusters within three of them, revealed that sustained community transmission was underway before the first COVID-19 case had been detected in Lombardy.

Original languageEnglish
Article number434
JournalNature Communications
Volume12
Issue number1
DOIs
Publication statusPublished - Dec 2021

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Fingerprint

Dive into the research topics of 'Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy'. Together they form a unique fingerprint.

Cite this