Genomic integration of HHV-6 mimicking viral reactivation after autologous stem cell transplantation

Research output: Contribution to journalArticle

Abstract

The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significant complications even after this type of transplant. Here we report, for the first time to our knowledge, the case of a patient with chromosomally integrated HHV-6 (ciHHV-6), presenting with high titers of HHV-6 DNA copies after autologous transplantation, mimicking HHV-6 reactivation. The presence of viral DNA in the follicle bulb confirmed the ciHHV-6 and allowed for the discontinuation of the antiviral treatment. Due to the increasing awareness of HHV-6 potential pathogenicity and the fact that ciHHV-6 is expected in 1-2% of the population, such a case might be helpful in recognizing ci HHV-6, thus avoiding unnecessary and potentially toxic antiviral therapy once the viral genomic integration is confirmed.

Original languageEnglish
Article numbere2018013
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Bone marrow transplantation
  • HHV-6 integration
  • Infectious disease

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

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