Genomic integration of HHV-6 mimicking viral reactivation after autologous stem cell transplantation

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The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significant complications even after this type of transplant. Here we report, for the first time to our knowledge, the case of a patient with chromosomally integrated HHV-6 (ciHHV-6), presenting with high titers of HHV-6 DNA copies after autologous transplantation, mimicking HHV-6 reactivation. The presence of viral DNA in the follicle bulb confirmed the ciHHV-6 and allowed for the discontinuation of the antiviral treatment. Due to the increasing awareness of HHV-6 potential pathogenicity and the fact that ciHHV-6 is expected in 1-2% of the population, such a case might be helpful in recognizing ci HHV-6, thus avoiding unnecessary and potentially toxic antiviral therapy once the viral genomic integration is confirmed.

Original languageEnglish
Article numbere2018013
JournalMediterranean Journal of Hematology and Infectious Diseases
Issue number1
Publication statusPublished - Jan 1 2018


  • Bone marrow transplantation
  • HHV-6 integration
  • Infectious disease

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases


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