Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer

Pamela L. Paris, Matthias D. Hofer, Giancarlo Albo, Rainer Kuefer, Juergen E. Gschwend, Richard E. Hautmann, Jane Fridyland, Jeffrey Simko, Peter R. Carroll, Mark A. Rubin, Colin Collins

Research output: Contribution to journalArticle

Abstract

The progression of organ-confined prostate cancer to metastatic cancer is inevitably fatal. Consequently, identification of structural changes in the genome and associated transcriptional responses that drive this progression is critical to understanding the disease process and the development of biomarkers and therapeutic targets. In this study, whole genome copy number changes in genomes of hormone-naïve lymph node metastases were profiled using array comparative genomic hybridization, and matched primaries were included for a subset. Matched primaries and lymph node metastases showed very similar copy number profiles that are distinct from primary tumors that fail to metastasize.

Original languageEnglish
Pages (from-to)1083-1089
Number of pages7
JournalNeoplasia (United States)
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 2006

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Keywords

  • aCGH
  • Biomarkers
  • Lymph nodes
  • Metastases
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research

Cite this

Paris, P. L., Hofer, M. D., Albo, G., Kuefer, R., Gschwend, J. E., Hautmann, R. E., Fridyland, J., Simko, J., Carroll, P. R., Rubin, M. A., & Collins, C. (2006). Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Neoplasia (United States), 8(12), 1083-1089. https://doi.org/10.1593/neo.06421