Genomic structure and chromosomal location of the human TGFβ-receptor interacting protein- 1 (TRIP-1) gene to 1p34.1

Claudia Galli-Stauber, Giovanna Raho, Daniela Rossi, Davide F V Corona, Barbara Pirola, Maria Clara Bonaglia, Orsetta Zuffardi, Vincenzo Sorrentino

Research output: Contribution to journalArticle

Abstract

The human TRIP-1 (transforming growth factor-β (TGBβ)-receptor interacting protein-l) cDNA encodes a protein able to associate specifically with the type II TGFβ receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFβ signal transduction pathway. We have isolated the genomic sequence of TRIP-1 and found that the complete coding region is organised into 11 exons ranging from 39 to 397 bp and spanning approximately 9 kb of genomic DNA. The 5' flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expressed gene which is in agreement with its wide pattern of expression. Fluorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalFEBS Letters
Volume426
Issue number2
DOIs
Publication statusPublished - Apr 17 1998

Keywords

  • TGFβ-receptor interacting protein-1
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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    Galli-Stauber, C., Raho, G., Rossi, D., Corona, D. F. V., Pirola, B., Bonaglia, M. C., Zuffardi, O., & Sorrentino, V. (1998). Genomic structure and chromosomal location of the human TGFβ-receptor interacting protein- 1 (TRIP-1) gene to 1p34.1. FEBS Letters, 426(2), 279-282. https://doi.org/10.1016/S0014-5793(98)00361-5