TY - JOUR
T1 - Genomic structure and chromosomal location of the human TGFβ-receptor interacting protein- 1 (TRIP-1) gene to 1p34.1
AU - Galli-Stauber, Claudia
AU - Raho, Giovanna
AU - Rossi, Daniela
AU - Corona, Davide F V
AU - Pirola, Barbara
AU - Bonaglia, Maria Clara
AU - Zuffardi, Orsetta
AU - Sorrentino, Vincenzo
PY - 1998/4/17
Y1 - 1998/4/17
N2 - The human TRIP-1 (transforming growth factor-β (TGBβ)-receptor interacting protein-l) cDNA encodes a protein able to associate specifically with the type II TGFβ receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFβ signal transduction pathway. We have isolated the genomic sequence of TRIP-1 and found that the complete coding region is organised into 11 exons ranging from 39 to 397 bp and spanning approximately 9 kb of genomic DNA. The 5' flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expressed gene which is in agreement with its wide pattern of expression. Fluorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32.
AB - The human TRIP-1 (transforming growth factor-β (TGBβ)-receptor interacting protein-l) cDNA encodes a protein able to associate specifically with the type II TGFβ receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFβ signal transduction pathway. We have isolated the genomic sequence of TRIP-1 and found that the complete coding region is organised into 11 exons ranging from 39 to 397 bp and spanning approximately 9 kb of genomic DNA. The 5' flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expressed gene which is in agreement with its wide pattern of expression. Fluorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32.
KW - TGFβ-receptor interacting protein-1
KW - Transforming growth factor-β
UR - http://www.scopus.com/inward/record.url?scp=0032540522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032540522&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(98)00361-5
DO - 10.1016/S0014-5793(98)00361-5
M3 - Article
C2 - 9599024
AN - SCOPUS:0032540522
VL - 426
SP - 279
EP - 282
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 2
ER -