Abstract
Acute myeloid leukemia (AML) is, as other types of cancer, a genetic disorder of somatic cells. The detection of somatic molecular abnormalities that may cause and maintain AML is crucial for patient stratification. The development of mutation-specific therapeutic interventions will hopefully increase cure rates and improve patients' quality of life. This review illustrates how next generation sequencing technologies are changing the study of cancer genomics of adult AML patients.
| Original language | English |
|---|---|
| Article number | Article 40 |
| Journal | Frontiers in Oncology |
| Volume | 2 MAY |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- Acute myeloid leukemia
- Next generation sequencing
- Recurrent mutations
- Somatic mutations
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Genomics of acute myeloid leukemia : The next generation. / Riva, Laura; Luzi, Lucilla; Pelicci, Pier Giuseppe.
In: Frontiers in Oncology, Vol. 2 MAY, Article 40, 2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genomics of acute myeloid leukemia
T2 - The next generation
AU - Riva, Laura
AU - Luzi, Lucilla
AU - Pelicci, Pier Giuseppe
PY - 2012
Y1 - 2012
N2 - Acute myeloid leukemia (AML) is, as other types of cancer, a genetic disorder of somatic cells. The detection of somatic molecular abnormalities that may cause and maintain AML is crucial for patient stratification. The development of mutation-specific therapeutic interventions will hopefully increase cure rates and improve patients' quality of life. This review illustrates how next generation sequencing technologies are changing the study of cancer genomics of adult AML patients.
AB - Acute myeloid leukemia (AML) is, as other types of cancer, a genetic disorder of somatic cells. The detection of somatic molecular abnormalities that may cause and maintain AML is crucial for patient stratification. The development of mutation-specific therapeutic interventions will hopefully increase cure rates and improve patients' quality of life. This review illustrates how next generation sequencing technologies are changing the study of cancer genomics of adult AML patients.
KW - Acute myeloid leukemia
KW - Next generation sequencing
KW - Recurrent mutations
KW - Somatic mutations
UR - http://www.scopus.com/inward/record.url?scp=84876985939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876985939&partnerID=8YFLogxK
U2 - 10.3389/fonc.2012.00040
DO - 10.3389/fonc.2012.00040
M3 - Article
AN - SCOPUS:84876985939
VL - 2 MAY
JO - Frontiers in Oncology
JF - Frontiers in Oncology
SN - 2234-943X
M1 - Article 40
ER -