Danno genotossico in esposti ad inquinanti atmosferici da traffico veicolare: risultati preliminari.

Translated title of the contribution: Genotoxic damage in subjects exposed to automobile exhaust: preliminary results

F. Merlo, C. Bolognesi, M. Peluso, F. Valerio, A. Abbondandolo, R. Puntoni

Research output: Contribution to journalArticle

Abstract

The associations between selected biomarkers of biologically effective dose (32P-post-labelling-DNA adducts), early biological effects (Micronuclei, MN) and sister chromatid exchanges (SCE) and individual measurements of exposure to benzo(a)pyrene (a surrogate index of exposure to polynuclear aromatic hydrocarbons, PAHs) are investigated in a study being conducted among traffic police workers and referent subjects in the City of Genova, Italy. Preliminary findings show B(a)P mean values of 1.33 ng/m3, SD = 1.35 ng/m3 and 0.06, SD = 0.17 in traffic police workers and referent subjects, respectively. Micronuclei mean levels in peripheral blood lymphocytes of 26 traffic police workers and 25 referents were 3.30, DS = 1.24 e 3.90, DS = 1.50 (per 1,000 binucleated cells). Eleven subjects (61%) out of 18 had detectable levels of DNA adducts (32P-post-labelling technique, range 1.8-9.0 Relative Adduct Level (RAL) per 10(9) nucleotides).

Translated title of the contributionGenotoxic damage in subjects exposed to automobile exhaust: preliminary results
Original languageItalian
Pages (from-to)120-123
Number of pages4
JournalEpidemiologia e prevenzione
Volume19
Issue number62
Publication statusPublished - Mar 1995

ASJC Scopus subject areas

  • Medicine(all)

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