Danno genotossico in esposti ad inquinanti atmosferici da traffico veicolare: risultati preliminari.

F. Merlo; C. Bolognesi; M. Peluso; F. Valerio; A. Abbondandolo; R. Puntoni

Danno genotossico in esposti ad inquinanti atmosferici da traffico veicolare: risultati preliminari.

Translated title of the contribution: Genotoxic damage in subjects exposed to automobile exhaust: preliminary results

F. Merlo, C. Bolognesi, M. Peluso, F. Valerio, A. Abbondandolo, R. Puntoni

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article

Abstract

The associations between selected biomarkers of biologically effective dose (32P-post-labelling-DNA adducts), early biological effects (Micronuclei, MN) and sister chromatid exchanges (SCE) and individual measurements of exposure to benzo(a)pyrene (a surrogate index of exposure to polynuclear aromatic hydrocarbons, PAHs) are investigated in a study being conducted among traffic police workers and referent subjects in the City of Genova, Italy. Preliminary findings show B(a)P mean values of 1.33 ng/m3, SD = 1.35 ng/m3 and 0.06, SD = 0.17 in traffic police workers and referent subjects, respectively. Micronuclei mean levels in peripheral blood lymphocytes of 26 traffic police workers and 25 referents were 3.30, DS = 1.24 e 3.90, DS = 1.50 (per 1,000 binucleated cells). Eleven subjects (61%) out of 18 had detectable levels of DNA adducts (32P-post-labelling technique, range 1.8-9.0 Relative Adduct Level (RAL) per 10(9) nucleotides).

Translated title of the contribution	Genotoxic damage in subjects exposed to automobile exhaust: preliminary results
Original language	Italian
Pages (from-to)	120-123
Number of pages	4
Journal	Epidemiologia e prevenzione
Volume	19
Issue number	62
Publication status	Published - Mar 1995

ASJC Scopus subject areas

Medicine(all)

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@article{35ef1705659d452a83a15d10d20be2a4,

title = "Danno genotossico in esposti ad inquinanti atmosferici da traffico veicolare: risultati preliminari.",

abstract = "The associations between selected biomarkers of biologically effective dose (32P-post-labelling-DNA adducts), early biological effects (Micronuclei, MN) and sister chromatid exchanges (SCE) and individual measurements of exposure to benzo(a)pyrene (a surrogate index of exposure to polynuclear aromatic hydrocarbons, PAHs) are investigated in a study being conducted among traffic police workers and referent subjects in the City of Genova, Italy. Preliminary findings show B(a)P mean values of 1.33 ng/m3, SD = 1.35 ng/m3 and 0.06, SD = 0.17 in traffic police workers and referent subjects, respectively. Micronuclei mean levels in peripheral blood lymphocytes of 26 traffic police workers and 25 referents were 3.30, DS = 1.24 e 3.90, DS = 1.50 (per 1,000 binucleated cells). Eleven subjects (61%) out of 18 had detectable levels of DNA adducts (32P-post-labelling technique, range 1.8-9.0 Relative Adduct Level (RAL) per 10(9) nucleotides).",

author = "F. Merlo and C. Bolognesi and M. Peluso and F. Valerio and A. Abbondandolo and R. Puntoni",

year = "1995",

month = mar,

language = "Italian",

volume = "19",

pages = "120--123",

journal = "Epidemiologia e prevenzione",

issn = "1120-9763",

publisher = "Zadig s.r.l",

number = "62",

}

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T1 - Danno genotossico in esposti ad inquinanti atmosferici da traffico veicolare

T2 - risultati preliminari.

AU - Merlo, F.

AU - Bolognesi, C.

AU - Peluso, M.

AU - Valerio, F.

AU - Abbondandolo, A.

AU - Puntoni, R.

PY - 1995/3

Y1 - 1995/3

N2 - The associations between selected biomarkers of biologically effective dose (32P-post-labelling-DNA adducts), early biological effects (Micronuclei, MN) and sister chromatid exchanges (SCE) and individual measurements of exposure to benzo(a)pyrene (a surrogate index of exposure to polynuclear aromatic hydrocarbons, PAHs) are investigated in a study being conducted among traffic police workers and referent subjects in the City of Genova, Italy. Preliminary findings show B(a)P mean values of 1.33 ng/m3, SD = 1.35 ng/m3 and 0.06, SD = 0.17 in traffic police workers and referent subjects, respectively. Micronuclei mean levels in peripheral blood lymphocytes of 26 traffic police workers and 25 referents were 3.30, DS = 1.24 e 3.90, DS = 1.50 (per 1,000 binucleated cells). Eleven subjects (61%) out of 18 had detectable levels of DNA adducts (32P-post-labelling technique, range 1.8-9.0 Relative Adduct Level (RAL) per 10(9) nucleotides).

AB - The associations between selected biomarkers of biologically effective dose (32P-post-labelling-DNA adducts), early biological effects (Micronuclei, MN) and sister chromatid exchanges (SCE) and individual measurements of exposure to benzo(a)pyrene (a surrogate index of exposure to polynuclear aromatic hydrocarbons, PAHs) are investigated in a study being conducted among traffic police workers and referent subjects in the City of Genova, Italy. Preliminary findings show B(a)P mean values of 1.33 ng/m3, SD = 1.35 ng/m3 and 0.06, SD = 0.17 in traffic police workers and referent subjects, respectively. Micronuclei mean levels in peripheral blood lymphocytes of 26 traffic police workers and 25 referents were 3.30, DS = 1.24 e 3.90, DS = 1.50 (per 1,000 binucleated cells). Eleven subjects (61%) out of 18 had detectable levels of DNA adducts (32P-post-labelling technique, range 1.8-9.0 Relative Adduct Level (RAL) per 10(9) nucleotides).

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