Genotoxic risk in rubber manufacturing industry: A systematic review

Claudia Bolognesi, Angelo Moretto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A large body of evidence from epidemiological studies among workers employed in the rubber manufacturing industry has indicated a significant excess cancer risk in a variety of sites. The International Agency for Research on Cancer has recently classified the "Occupational exposures in the rubber-manufacturing industry" as carcinogenic to humans (Group 1). A genotoxic mechanism for the increased cancer risk was suggested on the basis of the evidence from the scientific literature. Exposure assessment studies have shown that workers in the rubber manufacturing industry may be exposed to different airborne carcinogenic and/or genotoxic chemicals, such as certain aromatic amines, polycyclic aromatic hydrocarbons, N-nitrosamines, although the available information does not allow to establish a causal association of cancer or genotoxic risk with particular substances/classes of chemicals or specific jobs. The aim of this paper is to critically evaluate, by conducting a systematic review, the available biomonitoring studies using genotoxicity biomarkers in rubber manufacturing industry. This systematic review suggests that a genotoxic hazard may still be present in certain rubber manufacturing industries. A quantitative risk assessment needs further studies addressing the different, processes and chemicals in the rubber manufacturing industries.

Original languageEnglish
Pages (from-to)345-355
Number of pages11
JournalToxicology Letters
Volume230
Issue number2
DOIs
Publication statusPublished - Oct 5 2014

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Rubber
Industry
Neoplasms
Chemical Phenomena
International Agencies
Literature
Nitrosamines
Environmental Monitoring
Polycyclic Aromatic Hydrocarbons
Biomarkers
Occupational Exposure
Risk assessment
Amines
Manufacturing Industry
Epidemiologic Studies
Hazards
Association reactions
Research

Keywords

  • DNA adducts
  • Genotoxicity
  • Mutagenicity
  • Occupational exposure
  • Rubber manufacturing industry
  • Tire manufacturing

ASJC Scopus subject areas

  • Toxicology
  • Medicine(all)

Cite this

Genotoxic risk in rubber manufacturing industry : A systematic review. / Bolognesi, Claudia; Moretto, Angelo.

In: Toxicology Letters, Vol. 230, No. 2, 05.10.2014, p. 345-355.

Research output: Contribution to journalArticle

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