Genotoxicity of metal oxide nanomaterials: Review of recent data and discussion of possible mechanisms

Nazanin Golbamaki, Bakhtiyor Rasulev, Antonio Cassano, Richard L. Marchese Robinson, Emilio Benfenati, Jerzy Leszczynski, Mark T D Cronin

Research output: Contribution to journalArticle

Abstract

Nanotechnology has rapidly entered into human society, revolutionized many areas, including technology, medicine and cosmetics. This progress is due to the many valuable and unique properties that nanomaterials possess. In turn, these properties might become an issue of concern when considering potentially uncontrolled release to the environment. The rapid development of new nanomaterials thus raises questions about their impact on the environment and human health. This review focuses on the potential of nanomaterials to cause genotoxicity and summarizes recent genotoxicity studies on metal oxide/silica nanomaterials. Though the number of genotoxicity studies on metal oxide/silica nanomaterials is still limited, this endpoint has recently received more attention for nanomaterials, and the number of related publications has increased. An analysis of these peer reviewed publications over nearly two decades shows that the test most employed to evaluate the genotoxicity of these nanomaterials is the comet assay, followed by micronucleus, Ames and chromosome aberration tests. Based on the data studied, we concluded that in the majority of the publications analysed in this review, the metal oxide (or silica) nanoparticles of the same core chemical composition did not show different genotoxicity study calls (i.e. positive or negative) in the same test, although some results are inconsistent and need to be confirmed by additional experiments. Where the results are conflicting, it may be due to the following reasons: (1) variation in size of the nanoparticles; (2) variations in size distribution; (3) various purities of nanomaterials; (4) variation in surface areas for nanomaterials with the same average size; (5) differences in coatings; (6) differences in crystal structures of the same types of nanomaterials; (7) differences in size of aggregates in solution/media; (8) differences in assays; (9) different concentrations of nanomaterials in assay tests. Indeed, due to the observed inconsistencies in the recent literature and the lack of adherence to appropriate, standardized test methods, reliable genotoxicity assessment of nanomaterials is still challenging.

Original languageEnglish
Pages (from-to)2154-2198
Number of pages45
JournalNanoscale
Volume7
Issue number6
DOIs
Publication statusPublished - Feb 14 2015

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Nanostructures
Nanostructured materials
Oxides
Metals
Silicon Dioxide
Assays
Silica
Nanoparticles
Publications
Nanotechnology
Comet Assay
Cosmetics
Chromosomes
Aberrations
Chromosome Aberrations
Medicine
Crystal structure
Health

ASJC Scopus subject areas

  • Materials Science(all)
  • Medicine(all)

Cite this

Golbamaki, N., Rasulev, B., Cassano, A., Marchese Robinson, R. L., Benfenati, E., Leszczynski, J., & Cronin, M. T. D. (2015). Genotoxicity of metal oxide nanomaterials: Review of recent data and discussion of possible mechanisms. Nanoscale, 7(6), 2154-2198. https://doi.org/10.1039/c4nr06670g

Genotoxicity of metal oxide nanomaterials : Review of recent data and discussion of possible mechanisms. / Golbamaki, Nazanin; Rasulev, Bakhtiyor; Cassano, Antonio; Marchese Robinson, Richard L.; Benfenati, Emilio; Leszczynski, Jerzy; Cronin, Mark T D.

In: Nanoscale, Vol. 7, No. 6, 14.02.2015, p. 2154-2198.

Research output: Contribution to journalArticle

Golbamaki, N, Rasulev, B, Cassano, A, Marchese Robinson, RL, Benfenati, E, Leszczynski, J & Cronin, MTD 2015, 'Genotoxicity of metal oxide nanomaterials: Review of recent data and discussion of possible mechanisms', Nanoscale, vol. 7, no. 6, pp. 2154-2198. https://doi.org/10.1039/c4nr06670g
Golbamaki N, Rasulev B, Cassano A, Marchese Robinson RL, Benfenati E, Leszczynski J et al. Genotoxicity of metal oxide nanomaterials: Review of recent data and discussion of possible mechanisms. Nanoscale. 2015 Feb 14;7(6):2154-2198. https://doi.org/10.1039/c4nr06670g
Golbamaki, Nazanin ; Rasulev, Bakhtiyor ; Cassano, Antonio ; Marchese Robinson, Richard L. ; Benfenati, Emilio ; Leszczynski, Jerzy ; Cronin, Mark T D. / Genotoxicity of metal oxide nanomaterials : Review of recent data and discussion of possible mechanisms. In: Nanoscale. 2015 ; Vol. 7, No. 6. pp. 2154-2198.
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