Abstract
Rationale: The forced-swimming test (FST) is utilized to reproduce passive coping responses to stress that may model a relevant aspect of human depression in rodent species. Animals showing high levels of passive responses to the FST are assumed to model pathologically depressed individuals. Objectives: We evaluated sensitivity of FST-induced behavioral responses to the interaction between genetic and environmental influences. Methods: Behavioral responses to FST were evaluated in naive mice of the C57BL/6 and DBA/2 strains, in mice of both strains pre-exposed to FST 14 days before test, and in FST-experienced animals subsequently exposed to 12 days of stress experience (food restriction). Results: C57BL/6 mice are characterized by high propensity to adopt passive coping responses in the FST. Moreover, stress enhances FST-induced immobility in mice of the C57BL/6 strain but reduces this response in DBA/2 mice. Finally, FST-induced immobility in C57BL/6 mice is reduced by chronic treatment with clinically effective antidepressants. Conclusions: These results support the view that behavioral and neural responses to FST exhibited by C57BL/6 mice can be usefully exploited by pre-clinical research on depression.
| Original language | English |
|---|---|
| Pages (from-to) | 138-143 |
| Number of pages | 6 |
| Journal | Psychopharmacology |
| Volume | 164 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Amphetamine
- Clomipramine
- Depression
- Desipramine
- Diathesis stress
- FST
- Genotype
ASJC Scopus subject areas
- Pharmacology
Cite this
Genotype- and experience-dependent susceptibility to depressive-like responses in the forced-swimming test. / Alcaro, Antonio; Cabib, Simona; Ventura, Rossella; Puglisi-Allegra, Stefano.
In: Psychopharmacology, Vol. 164, No. 2, 2002, p. 138-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genotype- and experience-dependent susceptibility to depressive-like responses in the forced-swimming test
AU - Alcaro, Antonio
AU - Cabib, Simona
AU - Ventura, Rossella
AU - Puglisi-Allegra, Stefano
PY - 2002
Y1 - 2002
N2 - Rationale: The forced-swimming test (FST) is utilized to reproduce passive coping responses to stress that may model a relevant aspect of human depression in rodent species. Animals showing high levels of passive responses to the FST are assumed to model pathologically depressed individuals. Objectives: We evaluated sensitivity of FST-induced behavioral responses to the interaction between genetic and environmental influences. Methods: Behavioral responses to FST were evaluated in naive mice of the C57BL/6 and DBA/2 strains, in mice of both strains pre-exposed to FST 14 days before test, and in FST-experienced animals subsequently exposed to 12 days of stress experience (food restriction). Results: C57BL/6 mice are characterized by high propensity to adopt passive coping responses in the FST. Moreover, stress enhances FST-induced immobility in mice of the C57BL/6 strain but reduces this response in DBA/2 mice. Finally, FST-induced immobility in C57BL/6 mice is reduced by chronic treatment with clinically effective antidepressants. Conclusions: These results support the view that behavioral and neural responses to FST exhibited by C57BL/6 mice can be usefully exploited by pre-clinical research on depression.
AB - Rationale: The forced-swimming test (FST) is utilized to reproduce passive coping responses to stress that may model a relevant aspect of human depression in rodent species. Animals showing high levels of passive responses to the FST are assumed to model pathologically depressed individuals. Objectives: We evaluated sensitivity of FST-induced behavioral responses to the interaction between genetic and environmental influences. Methods: Behavioral responses to FST were evaluated in naive mice of the C57BL/6 and DBA/2 strains, in mice of both strains pre-exposed to FST 14 days before test, and in FST-experienced animals subsequently exposed to 12 days of stress experience (food restriction). Results: C57BL/6 mice are characterized by high propensity to adopt passive coping responses in the FST. Moreover, stress enhances FST-induced immobility in mice of the C57BL/6 strain but reduces this response in DBA/2 mice. Finally, FST-induced immobility in C57BL/6 mice is reduced by chronic treatment with clinically effective antidepressants. Conclusions: These results support the view that behavioral and neural responses to FST exhibited by C57BL/6 mice can be usefully exploited by pre-clinical research on depression.
KW - Amphetamine
KW - Clomipramine
KW - Depression
KW - Desipramine
KW - Diathesis stress
KW - FST
KW - Genotype
UR - http://www.scopus.com/inward/record.url?scp=0036914013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036914013&partnerID=8YFLogxK
U2 - 10.1007/s00213-002-1161-8
DO - 10.1007/s00213-002-1161-8
M3 - Article
C2 - 12404075
AN - SCOPUS:0036914013
VL - 164
SP - 138
EP - 143
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 2
ER -