Genotype-dependent modulation of LY 171555-induced defensive behavior in the mouse

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The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the seme strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.

Original languageEnglish
Pages (from-to)166-168
Number of pages3
Issue number2
Publication statusPublished - Feb 1989


  • D2 dopamine receptors
  • Defensive behaviors
  • Genotype
  • LY 171555

ASJC Scopus subject areas

  • Pharmacology


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