Genotype-dependent modulation of LY 171555-induced defensive behavior in the mouse

Simona Cabib; Stefano Puglisi-Allegra

doi:10.1007/BF00442243

Genotype-dependent modulation of LY 171555-induced defensive behavior in the mouse

Simona Cabib, Stefano Puglisi-Allegra

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the seme strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.

Original language	English
Pages (from-to)	166-168
Number of pages	3
Journal	Psychopharmacology
Volume	97
Issue number	2
DOIs	https://doi.org/10.1007/BF00442243
Publication status	Published - Feb 1989

Keywords

D2 dopamine receptors
Defensive behaviors
Genotype
LY 171555

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00442243

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title = "Genotype-dependent modulation of LY 171555-induced defensive behavior in the mouse",

abstract = "The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the seme strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.",

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N2 - The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the seme strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.

AB - The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the seme strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.

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Genotype-dependent modulation of LY 171555-induced defensive behavior in the mouse

Abstract

Keywords

ASJC Scopus subject areas

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