Abstract
The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the seme strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.
Original language | English |
---|---|
Pages (from-to) | 166-168 |
Number of pages | 3 |
Journal | Psychopharmacology |
Volume | 97 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1989 |
Keywords
- D2 dopamine receptors
- Defensive behaviors
- Genotype
- LY 171555
ASJC Scopus subject areas
- Pharmacology