Genotype of inflammatory cytokines in limbal stem cell graft in Italian patients

Francesco Lescai, Luigi Conti, Maurizio Bartolozzi, Giulia Ramazzotti, Marta Mazzi, Vincenzo Sarnicola, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

We tested the hypothesis that the genetic capability to mount an inflammatory response might contribute to the inter-individual variability of limbal stem cell graft (LSCG) outcome. Two functional polymorphisms in the IL-6 and TNF-α promoter regions were genotyped in 35 patients. A new score system (clinical assessment score, CAS) was set up in order to classify patients' clinical profile, and the main parameters relevant for LSCG as well as for the follow-up of the patients. Patients carrying at both loci a genotype associated with a lower production of both cytokines were classified as "low producers" (LP), while all the others were classified as "intermediate or high producers" (HP). LP patients did not show any difference in CAS before and after transplantation while a significant difference was present in HP patients. A similar trend was evident in the 35 months of follow-up. Polymorphisms of IL-6 and TNF-α can be used to identify subgroups of patients with higher risk of unsuccessful outcome.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume332
Issue number1
DOIs
Publication statusPublished - Jun 24 2005

Keywords

  • Genetics
  • IL-6
  • Inflammation
  • Limbal stem cell allograft
  • TNF-α

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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