Genotypic determination of HIV tropism in a cohort of patients perinatally infected with HIV-1 and exposed to antiretroviral therapy

Antonio Di Biagio, Andrea Parisini, Bianca Bruzzone, Roberta Prinapori, Marinella Lauriola, Stefania Paolucci, Alessio Signori, Renata Barresi, Giancarlo Icardi, Silvia Calderisi, Genny Meini, Chiara Dentone, Giovanni Cenderello, Michele Guerra, Anna Maccabruni, Stefano Rusconi, Claudio Viscoli

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to determine the coreceptor tropism by performing genotypic HIV-1 tropism testing in a cohort of patients perinatally infected with HIV-1 and exposed to antiretroviral therapy. Genotypic coreceptor tropism was determined in patients with HIV-1 RNA3 (474-905) and 32.5% in group R5 and 626 cells/mm3 (450-755) and 31.7% in group X4/D-M, respectively. The nadir of CD4+ T-cell count in groups R5 and X4/D-M were 322 cells/mm3 (230-427) and 340 cells/mm3 (242-356), respectively. These differences were not statistically significant. Fifteen patients had HIV-1 RNA â‰̄50 copies/mL. The median HIV-1 RNA and HIV-1 DNA were comparable in both groups without a statistical difference. The study provides an overview of the prevalence of coreceptor tropism in a cohort of patients who were vertically infected with HIV-1. The high prevalence of X4/D-M-tropic strains may simply reflect the long-term exposure to HIV.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalHIV Clinical Trials
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

Keywords

  • adolescents
  • CCR5 antagonists
  • children
  • coreceptor tropism
  • HIV-1 DNA
  • V3 genotyping
  • vertical transmission

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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