TY - JOUR
T1 - Genotypic resistance to lopinavir and fosamprenavir with or without ritonavir of clinical isolates from patients failing protease inhibitors-containing HAART regimens
T2 - Prevalence and predictors
AU - Giambenedetto, Simona Di
AU - Bacarelli, Alessanra
AU - Pinnetti, Carmen
AU - Colafigli, Manuela
AU - Prosperi, Mattia
AU - Gatti, Giorgio
AU - Cauda, Roberto
AU - De Luca, Andrea
PY - 2007
Y1 - 2007
N2 - The aim of this study was to establish the prevalence and predictors of genotypic resistance of HIV-1 to lopinavir and fosamprenavir from patients failing protease inhibitors (PI)-based regimens. We selected 643 HIV-1-infected patients with available treatment history who underwent genotypic resistance assays for virological failure from a clinical site and from the Stanford database. According to the genotypic resistance interpretation of the Stanford algorithm, proportions of viruses showing full susceptibility to fosamprenavir and lopinavir were 32% and 34%, respectively (p =ns). Proportions of viruses fully susceptible to lopinavir/r and fosamprenavir/r according to the Agence Nationale pour la Recherche sur le SIDA (ANRS) algorithm, were 81% and 81%, respectively. According to the Rega algorithm, proportions of viruses showing full susceptibility to fosamprenavir/r and lopinavir were 80% and 70%, respectively (p
AB - The aim of this study was to establish the prevalence and predictors of genotypic resistance of HIV-1 to lopinavir and fosamprenavir from patients failing protease inhibitors (PI)-based regimens. We selected 643 HIV-1-infected patients with available treatment history who underwent genotypic resistance assays for virological failure from a clinical site and from the Stanford database. According to the genotypic resistance interpretation of the Stanford algorithm, proportions of viruses showing full susceptibility to fosamprenavir and lopinavir were 32% and 34%, respectively (p =ns). Proportions of viruses fully susceptible to lopinavir/r and fosamprenavir/r according to the Agence Nationale pour la Recherche sur le SIDA (ANRS) algorithm, were 81% and 81%, respectively. According to the Rega algorithm, proportions of viruses showing full susceptibility to fosamprenavir/r and lopinavir were 80% and 70%, respectively (p
UR - http://www.scopus.com/inward/record.url?scp=34548139428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548139428&partnerID=8YFLogxK
U2 - 10.1080/00365540701367728
DO - 10.1080/00365540701367728
M3 - Article
C2 - 17701721
AN - SCOPUS:34548139428
VL - 39
SP - 813
EP - 818
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
SN - 0036-5548
IS - 9
ER -