Genotyping and fluconazole susceptibility of Candida albicans strains from patients with vulvovaginal candidiasis in Jos, Nigeria

Nnadi Nnaemeka Emmanuel, Orazio Romeo, Ayanbimpe Grace Mebi, Ojogba Okolo Mark, Fabio Scordino, Enweani Ifeoma Bessy, Giuseppe Criseo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the fluconazole susceptibility of the genotypes of Candida albicans (C. albicans) strains isolated from patients with vulvovaginal candidiasis (VVC) in Jos, Plateau State, Nigeria. Methods: A total of one hundred and seventy seven (177) Candida isolates were examined. The strains were obtained from 320 female patients with VVC and were identified using both phenotypic and molecular methods. Their genotypes were determined, based on the presence or absence of a transposable intron in the 25S rDNA. Results: Eighty four (84) strains were recognized as being C. albicans and all the 84 C. albicans strains resulted to be genotype A. Antifungal susceptibility testing showed that 13 of those isolates (15.48%) were resistant to fluconazole. Conclusions: Based on these data, we concluded that C. albicans genotype A was common among VVC patients in Jos, and resistance to fluconazole is quite high. To our knowledge, this is the first study that reports C. albicans genotypes in Jos and its resistance to fluconazole.

Original languageEnglish
Pages (from-to)48-50
Number of pages3
JournalAsian Pacific Journal of Tropical Disease
Volume2
Issue number1
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Candida albicans
  • Fluconazole
  • Genotypes
  • Polymerase chain reaction
  • Sensitivity

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

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