Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever

Susanna Esposito, Sonia Bianchini, Michele Fastiggi, Monica Fumagalli, Laura Andreozzi, Donato Rigante

Research output: Contribution to journalArticle

Abstract

Group A Streptococcus (GAS) strains are lately classified on the basis of sequence variations in the emm gene encoding the M protein, but despite the high number of distinct emm genotypes, the spectrum of phenotypes varying from invasive suppurative to non-suppurative GAS-related disorders has still to be defined. The relationship of GAS types with the uprising of acute rheumatic fever (ARF), a multisystemic disease caused by misdirected anti-GAS response in predisposed people, is also obscure. Studies published over the last 15. years were retrieved from PubMed using the keywords: ". Streptococcus pyogenes" or "group A Streptococcus" and "acute rheumatic fever": the prevalence of peculiar emm types across different countries of the world is highly variable, depending on research designs, year of observation, country involved, patients' age, and gender. Most studies revealed that a relatively small number of specific emm/M protein types can be considered "rheumatogenic", as potentially characterized by the possibility of inducing ARF, with remarkable differences between developing and developed countries. The association between emm types and post-streptococcal manifestations is challenging, however surveillance of disease-causing variants in a specific community with high rate of ARF should be reinforced with the final goal of developing a potential primary prophylaxis against GAS infections.

Original languageEnglish
Pages (from-to)616-621
Number of pages6
JournalAutoimmunity Reviews
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

Rheumatic Fever
Streptococcus pyogenes
Streptococcus
Developed Countries
PubMed
Developing Countries
Proteins
Research Design
Genotype
Observation
Phenotype
Infection
Genes

Keywords

  • Acute rheumatic fever
  • Group A Streptococcus
  • Streptococcal complication

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever. / Esposito, Susanna; Bianchini, Sonia; Fastiggi, Michele; Fumagalli, Monica; Andreozzi, Laura; Rigante, Donato.

In: Autoimmunity Reviews, Vol. 14, No. 7, 01.07.2015, p. 616-621.

Research output: Contribution to journalArticle

Esposito, Susanna ; Bianchini, Sonia ; Fastiggi, Michele ; Fumagalli, Monica ; Andreozzi, Laura ; Rigante, Donato. / Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever. In: Autoimmunity Reviews. 2015 ; Vol. 14, No. 7. pp. 616-621.
@article{18652a1458fb49f58a4c9535c4a0066c,
title = "Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever",
abstract = "Group A Streptococcus (GAS) strains are lately classified on the basis of sequence variations in the emm gene encoding the M protein, but despite the high number of distinct emm genotypes, the spectrum of phenotypes varying from invasive suppurative to non-suppurative GAS-related disorders has still to be defined. The relationship of GAS types with the uprising of acute rheumatic fever (ARF), a multisystemic disease caused by misdirected anti-GAS response in predisposed people, is also obscure. Studies published over the last 15. years were retrieved from PubMed using the keywords: {"}. Streptococcus pyogenes{"} or {"}group A Streptococcus{"} and {"}acute rheumatic fever{"}: the prevalence of peculiar emm types across different countries of the world is highly variable, depending on research designs, year of observation, country involved, patients' age, and gender. Most studies revealed that a relatively small number of specific emm/M protein types can be considered {"}rheumatogenic{"}, as potentially characterized by the possibility of inducing ARF, with remarkable differences between developing and developed countries. The association between emm types and post-streptococcal manifestations is challenging, however surveillance of disease-causing variants in a specific community with high rate of ARF should be reinforced with the final goal of developing a potential primary prophylaxis against GAS infections.",
keywords = "Acute rheumatic fever, Group A Streptococcus, Streptococcal complication",
author = "Susanna Esposito and Sonia Bianchini and Michele Fastiggi and Monica Fumagalli and Laura Andreozzi and Donato Rigante",
year = "2015",
month = "7",
day = "1",
doi = "10.1016/j.autrev.2015.03.001",
language = "English",
volume = "14",
pages = "616--621",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier",
number = "7",

}

TY - JOUR

T1 - Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever

AU - Esposito, Susanna

AU - Bianchini, Sonia

AU - Fastiggi, Michele

AU - Fumagalli, Monica

AU - Andreozzi, Laura

AU - Rigante, Donato

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Group A Streptococcus (GAS) strains are lately classified on the basis of sequence variations in the emm gene encoding the M protein, but despite the high number of distinct emm genotypes, the spectrum of phenotypes varying from invasive suppurative to non-suppurative GAS-related disorders has still to be defined. The relationship of GAS types with the uprising of acute rheumatic fever (ARF), a multisystemic disease caused by misdirected anti-GAS response in predisposed people, is also obscure. Studies published over the last 15. years were retrieved from PubMed using the keywords: ". Streptococcus pyogenes" or "group A Streptococcus" and "acute rheumatic fever": the prevalence of peculiar emm types across different countries of the world is highly variable, depending on research designs, year of observation, country involved, patients' age, and gender. Most studies revealed that a relatively small number of specific emm/M protein types can be considered "rheumatogenic", as potentially characterized by the possibility of inducing ARF, with remarkable differences between developing and developed countries. The association between emm types and post-streptococcal manifestations is challenging, however surveillance of disease-causing variants in a specific community with high rate of ARF should be reinforced with the final goal of developing a potential primary prophylaxis against GAS infections.

AB - Group A Streptococcus (GAS) strains are lately classified on the basis of sequence variations in the emm gene encoding the M protein, but despite the high number of distinct emm genotypes, the spectrum of phenotypes varying from invasive suppurative to non-suppurative GAS-related disorders has still to be defined. The relationship of GAS types with the uprising of acute rheumatic fever (ARF), a multisystemic disease caused by misdirected anti-GAS response in predisposed people, is also obscure. Studies published over the last 15. years were retrieved from PubMed using the keywords: ". Streptococcus pyogenes" or "group A Streptococcus" and "acute rheumatic fever": the prevalence of peculiar emm types across different countries of the world is highly variable, depending on research designs, year of observation, country involved, patients' age, and gender. Most studies revealed that a relatively small number of specific emm/M protein types can be considered "rheumatogenic", as potentially characterized by the possibility of inducing ARF, with remarkable differences between developing and developed countries. The association between emm types and post-streptococcal manifestations is challenging, however surveillance of disease-causing variants in a specific community with high rate of ARF should be reinforced with the final goal of developing a potential primary prophylaxis against GAS infections.

KW - Acute rheumatic fever

KW - Group A Streptococcus

KW - Streptococcal complication

UR - http://www.scopus.com/inward/record.url?scp=84928929534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928929534&partnerID=8YFLogxK

U2 - 10.1016/j.autrev.2015.03.001

DO - 10.1016/j.autrev.2015.03.001

M3 - Article

AN - SCOPUS:84928929534

VL - 14

SP - 616

EP - 621

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 7

ER -