Geoepidemiology of autoimmune liver diseases

Pietro Invernizzi

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Autoimmune liver diseases are characterized by immune mediated injury of bile ducts or hepatocytes, thus including cholangiopathies such as primary biliary cirrhosis, primary sclerosing cholangitis, and immunoglobulin G4-associated cholangitis, and autoimmune hepatitis. Although the liver was one of the earliest recognized sites of autoimmune aggression, the aetiology of autoimmune liver diseases remains largely obscure and their clinical management still difficult. Since an ever increasing applicability of immunology to a wide variety of chronic diseases, basic and clinical knowledge on autoimmune liver diseases grow rapidly in the last few years. This review will mainly focus on the available geoepidemiology data of these disorders, but it will deal also on their main clinical characteristics, as well as mechanisms of etiopathogenesis, for each of the above diseases, together with their overlap forms. In particular, we will discuss the major underlying immunomolecular mechanisms of development, the genetic influences, the growing number of immuno-serological diagnostic markers, and the increasingly effective therapeutic possibilities.

Original languageEnglish
JournalJournal of Autoimmunity
Volume34
Issue number3
DOIs
Publication statusPublished - May 2010

Fingerprint

Autoimmune Diseases
Liver Diseases
Autoimmune Hepatitis
Sclerosing Cholangitis
Cholangitis
Biliary Liver Cirrhosis
Allergy and Immunology
Bile Ducts
Aggression
Immunoglobulins
Hepatocytes
Chronic Disease
Liver
Wounds and Injuries
Therapeutics

Keywords

  • Clinical immunology
  • Geoepidemiology
  • Immunopathogenic processes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Geoepidemiology of autoimmune liver diseases. / Invernizzi, Pietro.

In: Journal of Autoimmunity, Vol. 34, No. 3, 05.2010.

Research output: Contribution to journalArticle

Invernizzi, Pietro. / Geoepidemiology of autoimmune liver diseases. In: Journal of Autoimmunity. 2010 ; Vol. 34, No. 3.
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