Geographic and demographic differences in the frequency of human cytomegalovirus gB genotypes 1-4 in immunocompromised patients

Donato Zipeto, Christina Hong, Giuseppe Gerna, Maurizio Zavattoni, David Katzenstein, Thomas C. Merigan, Lucy Rasmussen

Research output: Contribution to journalArticlepeer-review

Abstract

To test the hypothesis that human cytomegalovirus (CMV) gB genotype may differ with geographic origin or patient demographics, CMV DNA was amplified for gB typing from immunocompromised patients in Italy and Africa and compared with previously reported frequencies in California. Increased gB2 frequency occurred in Italian homosexual AIDS patients, as compared with both Italian heterosexual injection drug users with AIDS and heterosexual Zimbabwe AIDS patients. Occurrence of gB3 in Italy was higher in injection drug users than in homosexual AIDS patients. The incidence of gB4 was higher overall in the Italian as compared with the California patients. Therefore geographic and demographic differences in patients affect gB distribution and should be considered before associations of gB genotypes and virulence are made.

Original languageEnglish
Pages (from-to)533-536
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume14
Issue number6
Publication statusPublished - Apr 10 1998

ASJC Scopus subject areas

  • Immunology
  • Virology

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