Geographic differences in HBV related, autoimmune, and cryptogenic chronic active hepatitis

E. Sagnelli, M. Colombo, E. Del Ninno, S. J. Vernace, F. Paronetto

Research output: Contribution to journalArticlepeer-review

Abstract

To clarify the importance of ethnic and geographic factors in chronic active hepatitis (CAH), HBV markers and autoantibodies (AMA, ANA, SMA), have been compared in 158 patients with biopsy-proven CAH from New York City and in 92 patients with CAH from Milan. HBsAg-positive CAH was more frequently observed in Milan (49%) than in New York City (27%). However, among HBsAg-positive patients, HBcAg, HBeAg, and epidemiologic risk factors for acquisition of HBV infection were more frequently found in New York than in Italy. The prevalence of HBsAg-negative, anti-HBc-positive CAH and cryptogenic CAH was similar in the two cities, while autoimmune CAH was more frequently observed in New York (20%) than in Milan (2%). In particular, the prevalence of autoimmune hepatitis was higher among Jewish patients than among patients of Anglo-Saxon or Latin ethnic background in New York. Thus, environmental and/or ethnic factors may influence the prevalence of the four major types of CAH.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalLiver
Volume2
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Hepatology

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