GEP endocrine tumours imaging by means of a novel monoclonal antibody and the avidin/biotin system

P. Magnani, G. Paganelli, C. Songini, A. G. Siccardi, F. Fazio

Research output: Contribution to journalArticle

Abstract

Since chromogranins (Cg) are constitutively released by apudomas and are present in the intercellular matrix of such tumours, extracellular chromogranin deposits can be considered specific apudoma markers. We have evaluated, in 28 patients with GEP tumours, the efficacy of immunoscintigraphy (ISG) based on an anti-CgA monoclonal antibody and on the avidin-biotin 3-step method recently developed. We also have combined this new immunological approach with the somatostatin receptor related scan (Octreoscan-111) in 14 patients. Primary tumours or metastases were visualized in 21 patients. In the 14 patients studied both with ISG and Octreoscan, the same results were obtained. ISG is the first immunological method to detects apudomas. Its sensitivity (95%) is much higher than that (86%) of standard imaging techniques. The high specificity and tumour/non tumour ratios allow to view this method as the basis for immunotherapy developments. The use of ISG and Octreoscan-111 gave similar results in our series of patients, even if from a biological point of view informations obtained are quite different.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalMedecine Biologie Environment
Volume25
Issue number1
Publication statusPublished - 1997

Fingerprint

Avidin
Biotin
Apudoma
Tumors
Monoclonal Antibodies
Imaging techniques
Chromogranins
Neoplasms
Somatostatin Receptors
Immunotherapy
Deposits
Neoplasm Metastasis
pentetreotide

Keywords

  • Avidin/biotin
  • CgA
  • GEP tumours
  • ISG
  • Octreoscan

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

GEP endocrine tumours imaging by means of a novel monoclonal antibody and the avidin/biotin system. / Magnani, P.; Paganelli, G.; Songini, C.; Siccardi, A. G.; Fazio, F.

In: Medecine Biologie Environment, Vol. 25, No. 1, 1997, p. 9-13.

Research output: Contribution to journalArticle

Magnani, P. ; Paganelli, G. ; Songini, C. ; Siccardi, A. G. ; Fazio, F. / GEP endocrine tumours imaging by means of a novel monoclonal antibody and the avidin/biotin system. In: Medecine Biologie Environment. 1997 ; Vol. 25, No. 1. pp. 9-13.
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