Tumori a cellule germinali in età pediatrica

Translated title of the contribution: Germ cell tumors in childhood

M. Locurto, M. S. Lopiccolo, A. Arrighini, S. Bagnulo, C. Bernini, M. Carli, G. Cecchetto, E. Degrazia, T. Delaurentis, A. Dicataldo, M. R. Dipace, A. M. Fagnani, C. Favre, P. Indolfi, G. Marradi, F. Massolo, I. Mazzarino, L. Mazzeo, G. Menna, P. PutamignoN. Santoro, F. Siracusa, P. Tamaro, P. Targhetta, B. De Bernardi

Research output: Contribution to journalArticle

Abstract

In genuary 1991 a Protocol for Germ cell Tumors in children was actuated; 167 patients (pts.) were enrolled. Treatment was based on histology, site, staging. Mature Teratoma (T.): 73 pts.: 2 relapses, with malignant transformation in I case; all the pts. are alive without evident disease, after 3-65 mo. from diagnosis. Immature T.: 25 pts.: 5 relapses, with malignant trasformation in I case; all the pts. are alive, with residual mass in I case, lasting 3-59 mo. MNSGCT: 46 pts.: 1 pt. was no responder, 7 pts. had relapse: three of them with testicular tumor, are in II remission; 4 pts. died for progressive disease; four died for complications (one after relapse). Overall survival: 82,6%, with a median observation time of 30 mo. Fatal outcome occurred in 4/17 (23%) sacrococcigeal tumor and in the mediastinal tumor. Seminoma: 10 pts.: 2 relapses; all the pts. are alive after 15-65 mo. from diagnosis. Conclusion: long term surveillance is indicated in Mature T. The need for chemotherapy in Immature T. is no clear. Malignamt tumors are at high risk mainly for the s.c. localisation. Our data suggest tha reduction of chemotherapy in malignant localised tumors.

Original languageItalian
Pages (from-to)414-421
Number of pages8
JournalRivista Italiana di Pediatria
Volume23
Issue number3 SUPPL.
Publication statusPublished - 1997

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Germ Cell and Embryonal Neoplasms
Recurrence
Neoplasms
Drug Therapy
Seminoma
Fatal Outcome
Teratoma
Testicular Neoplasms
Histology
Observation
Survival

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Locurto, M., Lopiccolo, M. S., Arrighini, A., Bagnulo, S., Bernini, C., Carli, M., ... De Bernardi, B. (1997). Tumori a cellule germinali in età pediatrica. Rivista Italiana di Pediatria, 23(3 SUPPL.), 414-421.

Tumori a cellule germinali in età pediatrica. / Locurto, M.; Lopiccolo, M. S.; Arrighini, A.; Bagnulo, S.; Bernini, C.; Carli, M.; Cecchetto, G.; Degrazia, E.; Delaurentis, T.; Dicataldo, A.; Dipace, M. R.; Fagnani, A. M.; Favre, C.; Indolfi, P.; Marradi, G.; Massolo, F.; Mazzarino, I.; Mazzeo, L.; Menna, G.; Putamigno, P.; Santoro, N.; Siracusa, F.; Tamaro, P.; Targhetta, P.; De Bernardi, B.

In: Rivista Italiana di Pediatria, Vol. 23, No. 3 SUPPL., 1997, p. 414-421.

Research output: Contribution to journalArticle

Locurto, M, Lopiccolo, MS, Arrighini, A, Bagnulo, S, Bernini, C, Carli, M, Cecchetto, G, Degrazia, E, Delaurentis, T, Dicataldo, A, Dipace, MR, Fagnani, AM, Favre, C, Indolfi, P, Marradi, G, Massolo, F, Mazzarino, I, Mazzeo, L, Menna, G, Putamigno, P, Santoro, N, Siracusa, F, Tamaro, P, Targhetta, P & De Bernardi, B 1997, 'Tumori a cellule germinali in età pediatrica', Rivista Italiana di Pediatria, vol. 23, no. 3 SUPPL., pp. 414-421.
Locurto M, Lopiccolo MS, Arrighini A, Bagnulo S, Bernini C, Carli M et al. Tumori a cellule germinali in età pediatrica. Rivista Italiana di Pediatria. 1997;23(3 SUPPL.):414-421.
Locurto, M. ; Lopiccolo, M. S. ; Arrighini, A. ; Bagnulo, S. ; Bernini, C. ; Carli, M. ; Cecchetto, G. ; Degrazia, E. ; Delaurentis, T. ; Dicataldo, A. ; Dipace, M. R. ; Fagnani, A. M. ; Favre, C. ; Indolfi, P. ; Marradi, G. ; Massolo, F. ; Mazzarino, I. ; Mazzeo, L. ; Menna, G. ; Putamigno, P. ; Santoro, N. ; Siracusa, F. ; Tamaro, P. ; Targhetta, P. ; De Bernardi, B. / Tumori a cellule germinali in età pediatrica. In: Rivista Italiana di Pediatria. 1997 ; Vol. 23, No. 3 SUPPL. pp. 414-421.
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AU - Lopiccolo, M. S.

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AU - Bernini, C.

AU - Carli, M.

AU - Cecchetto, G.

AU - Degrazia, E.

AU - Delaurentis, T.

AU - Dicataldo, A.

AU - Dipace, M. R.

AU - Fagnani, A. M.

AU - Favre, C.

AU - Indolfi, P.

AU - Marradi, G.

AU - Massolo, F.

AU - Mazzarino, I.

AU - Mazzeo, L.

AU - Menna, G.

AU - Putamigno, P.

AU - Santoro, N.

AU - Siracusa, F.

AU - Tamaro, P.

AU - Targhetta, P.

AU - De Bernardi, B.

PY - 1997

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