Germinal ovarian tumors in reproductive age women: Fertility-sparing and outcome.

Miriam Dellino, Erica Silvestris, Vera Loizzi, Angelo Paradiso, Rosalia Loiacono, Carla Minoia, Antonella Daniele, Gennaro Cormio

Research output: Contribution to journalArticlepeer-review


MOGCTs (malignant ovarian germ cell tumors) are rare tumors that mainly affect patients of reproductive age. The aim of this study was to evaluate the fertility and survival outcomes in young women with MOCGTs treated with fertility-sparing surgery (FSS).From 2000 to 2018, data from 28 patients of reproductive age with a diagnosis of MOGCT at the University of Bari were collected. Most received FSS, and in patients treated conservatively, the reproductive outcome and survival were investigated. Data of patient demographics, clinical presentation, oncology marker dosage, staging, type of surgery, histological examination, survival, and reproductive outcome were collected from hospital and office charts. All informed consent was obtained from all patients. The median age was 24 (range: 9-45 years). The majority of the patients had stage IIIC. Twenty-four woman received FSS consisting of unilateral ovariectomy and omentectomy, whereas only 4 women, based on their stage (IIIC), received a radical surgery (hysterectomy with bilateral adnexectomy, lymphadenectomy, and omentectomy). Our study shows that FSS in MOGCTs can produce good results both on reproductive outcomes and on survival. Indeed, in our group, there was only 1 case of exitus as result of recurrence. Furthermore, patients after FSS maintained normal ovarian function and 5 of 5 women who tried to get pregnant succeeded spontaneously. The median follow-up was 90 months (range 3-159).Conservative surgery for MOGCTs should be considered for women of reproductive age who wish to preserve fertility.

Original languageEnglish
Article numbere22146
Issue number39
Publication statusPublished - Sep 25 2020


  • Adolescent
  • Adult
  • Child
  • Female
  • Fertility Preservation/methods
  • Humans
  • Middle Aged
  • Neoplasm Staging
  • Neoplasms, Germ Cell and Embryonal/pathology
  • Ovarian Neoplasms/pathology
  • Young Adult


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