Gestational trophoblastic disease: Psychological aspects and fertility issues

Valentina E. Di Mattei, Letizia Carnelli, Alessandro Ambrosi, Giorgia Mangili, Massimo Candiani, Lucio Sarno

Research output: Contribution to journalArticle


OBJECTIVE: To evaluate the impact of a forced delay in childbearing during the follow-up period on the perceived fertility of patients with gestational trophoblastic disease (GTD), and to investigate how women react to the monitoring period, with particular attention to fertility concerns, personal perceptions of the impact of GTD on reproductive outcomes, and psychological symptoms of depression and anxiety. STUDY DESIGN: Twenty women treated for GTD at San Raffaele Hospital, Milan, took part in the study. Depression, anxiety, and infertility-related stress were assessed using the Beck Depression Inventory–Short Form, the State-Trait Anxiety Inventory, and the Fertility Problem Inventory, respectively. RESULTS: A significant difference in depression levels was found between women with hydatiform mole and women with gestational trophoblastic neoplasia (p = 0.02). On the contrary, anxiety and depression levels did not vary on the basis of time elapsed since diagnosis, presence of children, and age (<35 years). A significant correlation was also found between anxiety (state and trait) and depression (ρs=0.62, p=0.002 and ρs=0.59, p = 0.005, respectively). There was no association between infertility-related stress and anxiety or depression or time elapsed since diagnosis. Additionally, such stress did not change between women with or without children. CONCLUSION: Women with GTD diagnosis should be followed by a multidisciplinary team so as to be supported in the disease’s psychological aspects, too.

Original languageEnglish
Pages (from-to)488-495
Number of pages8
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number5
Publication statusPublished - Oct 1 2014


  • Anxiety
  • Depression
  • Gestational trophoblastic disease
  • Gestational trophoblastic neoplasia
  • Infertility-related stress
  • Perceived fertility
  • Psychological aspects

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)

Fingerprint Dive into the research topics of 'Gestational trophoblastic disease: Psychological aspects and fertility issues'. Together they form a unique fingerprint.

  • Cite this