Getting lost in Alzheimer's disease: A break in the mental frame syncing

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Despite the clinical significance of topographical disorientation in Alzheimer's disease, it is not clear which cognitive spatial processes are primarily impaired. Here, we argue that a deficit in " mental frame syncing" between egocentric and allocentric spatial representations causes early manifestations of topographical disorientation in AD. Specifically, patients show impairment in translating from an allocentric hippocampal representation to an egocentric parietal one for the purpose of effective spatial orientation and navigation. We suggest that a break in " mental frame syncing" , underpinned by damage to the hippocampus and retrosplenial cortex, may be a crucial cognitive marker both for early and differential diagnosis of AD. Identification of these spatial deficits could facilitate the development of early cognitive rehabilitation interventions and the possibility of identifying individuals most at risk for progression to AD during the preclinical stages.

Original languageEnglish
Pages (from-to)416-421
Number of pages6
JournalMedical Hypotheses
Volume80
Issue number4
DOIs
Publication statusPublished - Apr 2013

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Confusion
Alzheimer Disease
Early Diagnosis
Hippocampus
Differential Diagnosis
Rehabilitation
Spatial Orientation
Spatial Navigation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Getting lost in Alzheimer's disease : A break in the mental frame syncing. / Serino, Silvia; Riva, Giuseppe.

In: Medical Hypotheses, Vol. 80, No. 4, 04.2013, p. 416-421.

Research output: Contribution to journalArticle

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