GH and IGF-I deficiency are associated with reduced loss of fat mass after laparoscopic-adjustable silicone gastric banding

Carolina Di Somma, Luigi Angrisani, Francesca Rota, Maria Cristina Savanelli, Teresa Cascella, Annamaria Belfiore, Francesco Orio, Gaetano Lombardi, Annamaria Colao, Silvia Savastano

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Context: GH secretion is reduced in obese subjects and increases after body weight loss. It is still unclear if changes in the GH/IGF-I axis after laparoscopic-adjustable silicone gastric banding (LASGB) are associated with changes of body composition. Objective: To analyse the relationships between changes in the GH/IGF-I axis and those of body weight and composition before and after LASGB. Design: Observational, prospective. Setting: University 'Federico II' of Naples (Italy). Patients: Seventy-two severely obese females (BMI: 44.9 ± 4.68; mean age: 33.1 ± 11.34 years) were studied. Main outcome measures: GH peak after GHRH plus arginine test, IGF-I, IGFBP-3 and ALS levels, fat mass (FM) and free fat mass (FFM) (by Bioelectrical Impedance Analysis) at baseline and 6 months after LASGB. The change in percentage of individual variables was calculated as well as that of excess of body weight loss (EBWL%). The FM%, FFM% and EBWL% were correlated with peak GH and IGF-I levels changes. Results: At baseline, GH deficiency (GHD) (GH peak = 4.1 μg/l) was found in 22 patients (31%), 16 of them also had IGF-I deficiency (<-2SDS). IGF-I levels were inversely correlated with waist circumference (r = -0.72, P <0.001) and FM% (r = -0.75, P <0.001). Post-LASGB the patients were classified as follows: group (1) GH and IGF-I sufficient (n = 44; 61.1%); group (2) GH and IGF-I deficient (n = 14; 19.4%) and group (3) GH sufficient and IGF-I deficient (n = 14; 19.4%). The percentage changes of EWBL (P <0.05, P = 0.051, respectively) and FM (P <0.001, P <0.01, respectively) were lower in groups (2) and (3) than in group (1). At the stepwise linear regression analysis, postoperative IGF-I levels were the strongest determinant of percent changes of FM (P <0.0001), of FFM (P = 0.009) and of EBWL (P <0.0001). Conclusions: IGF-I levels is the most sensitive to unfavourable changes in body composition 6 months after LASGB making investigation of the somatotropic axis useful in the evaluation of bariatric surgery outcomes.

Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalClinical Endocrinology
Volume69
Issue number3
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Silicones
Insulin-Like Growth Factor I
Stomach
Fats
Body Composition
Body Weight
Weight Loss
Insulin-Like Growth Factor Binding Protein 3
Bariatric Surgery
Waist Circumference
Electric Impedance
Italy
Arginine
Linear Models
Regression Analysis
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Endocrinology

Cite this

GH and IGF-I deficiency are associated with reduced loss of fat mass after laparoscopic-adjustable silicone gastric banding. / Di Somma, Carolina; Angrisani, Luigi; Rota, Francesca; Savanelli, Maria Cristina; Cascella, Teresa; Belfiore, Annamaria; Orio, Francesco; Lombardi, Gaetano; Colao, Annamaria; Savastano, Silvia.

In: Clinical Endocrinology, Vol. 69, No. 3, 09.2008, p. 393-399.

Research output: Contribution to journalArticle

Di Somma, C, Angrisani, L, Rota, F, Savanelli, MC, Cascella, T, Belfiore, A, Orio, F, Lombardi, G, Colao, A & Savastano, S 2008, 'GH and IGF-I deficiency are associated with reduced loss of fat mass after laparoscopic-adjustable silicone gastric banding', Clinical Endocrinology, vol. 69, no. 3, pp. 393-399. https://doi.org/10.1111/j.1365-2265.2008.03183.x
Di Somma, Carolina ; Angrisani, Luigi ; Rota, Francesca ; Savanelli, Maria Cristina ; Cascella, Teresa ; Belfiore, Annamaria ; Orio, Francesco ; Lombardi, Gaetano ; Colao, Annamaria ; Savastano, Silvia. / GH and IGF-I deficiency are associated with reduced loss of fat mass after laparoscopic-adjustable silicone gastric banding. In: Clinical Endocrinology. 2008 ; Vol. 69, No. 3. pp. 393-399.
@article{9af50d0fe7eb4ae280affee71f1d6850,
title = "GH and IGF-I deficiency are associated with reduced loss of fat mass after laparoscopic-adjustable silicone gastric banding",
abstract = "Context: GH secretion is reduced in obese subjects and increases after body weight loss. It is still unclear if changes in the GH/IGF-I axis after laparoscopic-adjustable silicone gastric banding (LASGB) are associated with changes of body composition. Objective: To analyse the relationships between changes in the GH/IGF-I axis and those of body weight and composition before and after LASGB. Design: Observational, prospective. Setting: University 'Federico II' of Naples (Italy). Patients: Seventy-two severely obese females (BMI: 44.9 ± 4.68; mean age: 33.1 ± 11.34 years) were studied. Main outcome measures: GH peak after GHRH plus arginine test, IGF-I, IGFBP-3 and ALS levels, fat mass (FM) and free fat mass (FFM) (by Bioelectrical Impedance Analysis) at baseline and 6 months after LASGB. The change in percentage of individual variables was calculated as well as that of excess of body weight loss (EBWL{\%}). The FM{\%}, FFM{\%} and EBWL{\%} were correlated with peak GH and IGF-I levels changes. Results: At baseline, GH deficiency (GHD) (GH peak = 4.1 μg/l) was found in 22 patients (31{\%}), 16 of them also had IGF-I deficiency (<-2SDS). IGF-I levels were inversely correlated with waist circumference (r = -0.72, P <0.001) and FM{\%} (r = -0.75, P <0.001). Post-LASGB the patients were classified as follows: group (1) GH and IGF-I sufficient (n = 44; 61.1{\%}); group (2) GH and IGF-I deficient (n = 14; 19.4{\%}) and group (3) GH sufficient and IGF-I deficient (n = 14; 19.4{\%}). The percentage changes of EWBL (P <0.05, P = 0.051, respectively) and FM (P <0.001, P <0.01, respectively) were lower in groups (2) and (3) than in group (1). At the stepwise linear regression analysis, postoperative IGF-I levels were the strongest determinant of percent changes of FM (P <0.0001), of FFM (P = 0.009) and of EBWL (P <0.0001). Conclusions: IGF-I levels is the most sensitive to unfavourable changes in body composition 6 months after LASGB making investigation of the somatotropic axis useful in the evaluation of bariatric surgery outcomes.",
author = "{Di Somma}, Carolina and Luigi Angrisani and Francesca Rota and Savanelli, {Maria Cristina} and Teresa Cascella and Annamaria Belfiore and Francesco Orio and Gaetano Lombardi and Annamaria Colao and Silvia Savastano",
year = "2008",
month = "9",
doi = "10.1111/j.1365-2265.2008.03183.x",
language = "English",
volume = "69",
pages = "393--399",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - GH and IGF-I deficiency are associated with reduced loss of fat mass after laparoscopic-adjustable silicone gastric banding

AU - Di Somma, Carolina

AU - Angrisani, Luigi

AU - Rota, Francesca

AU - Savanelli, Maria Cristina

AU - Cascella, Teresa

AU - Belfiore, Annamaria

AU - Orio, Francesco

AU - Lombardi, Gaetano

AU - Colao, Annamaria

AU - Savastano, Silvia

PY - 2008/9

Y1 - 2008/9

N2 - Context: GH secretion is reduced in obese subjects and increases after body weight loss. It is still unclear if changes in the GH/IGF-I axis after laparoscopic-adjustable silicone gastric banding (LASGB) are associated with changes of body composition. Objective: To analyse the relationships between changes in the GH/IGF-I axis and those of body weight and composition before and after LASGB. Design: Observational, prospective. Setting: University 'Federico II' of Naples (Italy). Patients: Seventy-two severely obese females (BMI: 44.9 ± 4.68; mean age: 33.1 ± 11.34 years) were studied. Main outcome measures: GH peak after GHRH plus arginine test, IGF-I, IGFBP-3 and ALS levels, fat mass (FM) and free fat mass (FFM) (by Bioelectrical Impedance Analysis) at baseline and 6 months after LASGB. The change in percentage of individual variables was calculated as well as that of excess of body weight loss (EBWL%). The FM%, FFM% and EBWL% were correlated with peak GH and IGF-I levels changes. Results: At baseline, GH deficiency (GHD) (GH peak = 4.1 μg/l) was found in 22 patients (31%), 16 of them also had IGF-I deficiency (<-2SDS). IGF-I levels were inversely correlated with waist circumference (r = -0.72, P <0.001) and FM% (r = -0.75, P <0.001). Post-LASGB the patients were classified as follows: group (1) GH and IGF-I sufficient (n = 44; 61.1%); group (2) GH and IGF-I deficient (n = 14; 19.4%) and group (3) GH sufficient and IGF-I deficient (n = 14; 19.4%). The percentage changes of EWBL (P <0.05, P = 0.051, respectively) and FM (P <0.001, P <0.01, respectively) were lower in groups (2) and (3) than in group (1). At the stepwise linear regression analysis, postoperative IGF-I levels were the strongest determinant of percent changes of FM (P <0.0001), of FFM (P = 0.009) and of EBWL (P <0.0001). Conclusions: IGF-I levels is the most sensitive to unfavourable changes in body composition 6 months after LASGB making investigation of the somatotropic axis useful in the evaluation of bariatric surgery outcomes.

AB - Context: GH secretion is reduced in obese subjects and increases after body weight loss. It is still unclear if changes in the GH/IGF-I axis after laparoscopic-adjustable silicone gastric banding (LASGB) are associated with changes of body composition. Objective: To analyse the relationships between changes in the GH/IGF-I axis and those of body weight and composition before and after LASGB. Design: Observational, prospective. Setting: University 'Federico II' of Naples (Italy). Patients: Seventy-two severely obese females (BMI: 44.9 ± 4.68; mean age: 33.1 ± 11.34 years) were studied. Main outcome measures: GH peak after GHRH plus arginine test, IGF-I, IGFBP-3 and ALS levels, fat mass (FM) and free fat mass (FFM) (by Bioelectrical Impedance Analysis) at baseline and 6 months after LASGB. The change in percentage of individual variables was calculated as well as that of excess of body weight loss (EBWL%). The FM%, FFM% and EBWL% were correlated with peak GH and IGF-I levels changes. Results: At baseline, GH deficiency (GHD) (GH peak = 4.1 μg/l) was found in 22 patients (31%), 16 of them also had IGF-I deficiency (<-2SDS). IGF-I levels were inversely correlated with waist circumference (r = -0.72, P <0.001) and FM% (r = -0.75, P <0.001). Post-LASGB the patients were classified as follows: group (1) GH and IGF-I sufficient (n = 44; 61.1%); group (2) GH and IGF-I deficient (n = 14; 19.4%) and group (3) GH sufficient and IGF-I deficient (n = 14; 19.4%). The percentage changes of EWBL (P <0.05, P = 0.051, respectively) and FM (P <0.001, P <0.01, respectively) were lower in groups (2) and (3) than in group (1). At the stepwise linear regression analysis, postoperative IGF-I levels were the strongest determinant of percent changes of FM (P <0.0001), of FFM (P = 0.009) and of EBWL (P <0.0001). Conclusions: IGF-I levels is the most sensitive to unfavourable changes in body composition 6 months after LASGB making investigation of the somatotropic axis useful in the evaluation of bariatric surgery outcomes.

UR - http://www.scopus.com/inward/record.url?scp=49649106078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49649106078&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2265.2008.03183.x

DO - 10.1111/j.1365-2265.2008.03183.x

M3 - Article

C2 - 18194484

AN - SCOPUS:49649106078

VL - 69

SP - 393

EP - 399

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 3

ER -