GH deficiency in adult B-thalassemia major patients and its relationship with IGF-1 production.

Angela Ida Pincelli, Nicoletta Masera, Luisa Tavecchia, Mario Perotti, Silvia Perra, Raffaela Mariani, Alberto Piperno, Giuseppe Mancia, Guido Grassi, Giuseppe Masera

Research output: Contribution to journalArticle

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Abstract

Endocrine complications in Β-thalassemia represent a prominent cause of morbidity. Above all, dysfunction of GH-IGF-1 axis is of a major concern because of its pathogenic role on cardiac and bone disease, frequently described in this clinical setting. The aim of this paper is to analyze GH-IGF-1 axis in a cohort of 25 adult patients affected by Β-thalassemia. We found that GH deficiency was present in only 8% of our patients if diagnosis was based on GH peak below 9μg/L to two GH provocative tests instead of only one, and was mainly related to iron overload. On the contrary, IGF-1 production was impaired in a higher percentage of patients (72%), without significant correlation with iron burden. Of note, patients with hepatitis C virus infection showed lower IGF-1 concentrations than uninfected subjects despite a normal GH reserve, suggesting that partial GH insensitivity at the post-receptor level may play a key role in IGF-1 deficiency described in thalassemic patients.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalPediatric Endocrinology Reviews
Volume8 Suppl 2
Publication statusPublished - Mar 2011

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beta-Thalassemia
Insulin-Like Growth Factor I
Thalassemia
Iron Overload
Bone Diseases
Virus Diseases
Hepacivirus
Heart Diseases
Iron
Morbidity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Pincelli, A. I., Masera, N., Tavecchia, L., Perotti, M., Perra, S., Mariani, R., ... Masera, G. (2011). GH deficiency in adult B-thalassemia major patients and its relationship with IGF-1 production. Pediatric Endocrinology Reviews, 8 Suppl 2, 284-289.

GH deficiency in adult B-thalassemia major patients and its relationship with IGF-1 production. / Pincelli, Angela Ida; Masera, Nicoletta; Tavecchia, Luisa; Perotti, Mario; Perra, Silvia; Mariani, Raffaela; Piperno, Alberto; Mancia, Giuseppe; Grassi, Guido; Masera, Giuseppe.

In: Pediatric Endocrinology Reviews, Vol. 8 Suppl 2, 03.2011, p. 284-289.

Research output: Contribution to journalArticle

Pincelli, AI, Masera, N, Tavecchia, L, Perotti, M, Perra, S, Mariani, R, Piperno, A, Mancia, G, Grassi, G & Masera, G 2011, 'GH deficiency in adult B-thalassemia major patients and its relationship with IGF-1 production.', Pediatric Endocrinology Reviews, vol. 8 Suppl 2, pp. 284-289.
Pincelli AI, Masera N, Tavecchia L, Perotti M, Perra S, Mariani R et al. GH deficiency in adult B-thalassemia major patients and its relationship with IGF-1 production. Pediatric Endocrinology Reviews. 2011 Mar;8 Suppl 2:284-289.
Pincelli, Angela Ida ; Masera, Nicoletta ; Tavecchia, Luisa ; Perotti, Mario ; Perra, Silvia ; Mariani, Raffaela ; Piperno, Alberto ; Mancia, Giuseppe ; Grassi, Guido ; Masera, Giuseppe. / GH deficiency in adult B-thalassemia major patients and its relationship with IGF-1 production. In: Pediatric Endocrinology Reviews. 2011 ; Vol. 8 Suppl 2. pp. 284-289.
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