GH deficiency in adult B-thalassemia major patients and its relationship with IGF-1 production.

Angela Ida Pincelli, Nicoletta Masera, Luisa Tavecchia, Mario Perotti, Silvia Perra, Raffaela Mariani, Alberto Piperno, Giuseppe Mancia, Guido Grassi, Giuseppe Masera

Research output: Contribution to journalArticlepeer-review


Endocrine complications in Β-thalassemia represent a prominent cause of morbidity. Above all, dysfunction of GH-IGF-1 axis is of a major concern because of its pathogenic role on cardiac and bone disease, frequently described in this clinical setting. The aim of this paper is to analyze GH-IGF-1 axis in a cohort of 25 adult patients affected by Β-thalassemia. We found that GH deficiency was present in only 8% of our patients if diagnosis was based on GH peak below 9μg/L to two GH provocative tests instead of only one, and was mainly related to iron overload. On the contrary, IGF-1 production was impaired in a higher percentage of patients (72%), without significant correlation with iron burden. Of note, patients with hepatitis C virus infection showed lower IGF-1 concentrations than uninfected subjects despite a normal GH reserve, suggesting that partial GH insensitivity at the post-receptor level may play a key role in IGF-1 deficiency described in thalassemic patients.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalPediatric Endocrinology Reviews
Volume8 Suppl 2
Publication statusPublished - Mar 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism


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