GH deficiency status combined with GH receptor polymorphism affects response to GH in children

Armand Valsesia, Pierre Chatelain, Adam Stevens, Valentina A. Peterkova, Alicia Belgorosky, Mohamad Maghnie, Franco Antoniazzi, Ekaterina Koledova, Jerome Wojcik, Pierre Farmer, Benoit Destenaves, Peter Clayton, G. Ambler, K. Kapelari, C. Deal, J. Hamilton, Y. Brusquet, P. Chatelain, M. Colle, R. CoutantS. Cabrol, Y. Le Bouc, R. Reynaud, J. P. Salles, J. Weill, R. Pfäffle, M. Ranke, G. Binder, M. Bozzola, F. Buzi, A. Pilotta, M. Cappa, A. Cicognani, S. Zucchini, M. Maghnie, F. Antoniazzi, L. Tatò, D. H. Kim, H. W. Yoo, S. W. Yang, E. Vangsøy Hansen, D. Veimo, E. Bashina, Y. Skorodok, V. Peterkova, L. Sultanova, A. Carrascosa, D. Yesta, A. Ferrandez Longas, R. Gracia Bouthellier, I. Gonzalez, M. D. Rodriguez-Arnao, A. Rodriguez-Sanchez, J. P. Lopez Siguero, S. Quinteiro, J. Dahlgren, L. Hagenäs, T. J. Wang, J. W. Hou, L. Bath, C. Kelnar, P. Clayton

Research output: Contribution to journalArticlepeer-review

Abstract

Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in relation to severity of GH deficiency (GHD) were investigated in patients from 14 countries. Treatment-naïve pre-pubertal children with GHD were enrolled from the PREDICT studies (NCT00256126 and NCT00699855), categorized by peak GH level (peak GH) during provocation test: ≤4 μg/l (severe GHD; n>45) and >4 to

Original languageEnglish
Pages (from-to)777-789
Number of pages13
JournalEuropean Journal of Endocrinology
Volume173
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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