GH response to ghrelin in subjects with congenital GH deficiency

Evidence that ghrelin action requires hypothalamic-pituitary connections

Mohamad Maghnie, Maria Cristina Pennati, Elisa Civardi, Natascia Di Iorgi, Gianluca Aimeretti, Maria Loreta Foschini, Ginevra Corneli, Carmine Tinelli, Ezio Ghigo, Renata Lorini, Sandro Loche

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: Evaluation of GH response to ghrelin in patients with GH deficiency (GHD) may help to elucidate the site and mechanism of action of ghrelin. We aimed to investigate the GH-releasing effect of ghrelin in children and young adults with childhood-onset GHD. Design: All subjects underwent ghrelin testing and neuro-imaging examination. Magnetic resonance imaging evidenced the presence of a vascular pituitary stalk (VPS) or its complete absence (PSA). Patients and methods: Seventeen prepubertal children and nine adult patients with childhood-onset GHD were selected for the study. The children were enrolled at a median age of 5.8 years. The adult subjects were included at a median age of 23.3 years. The diagnosis of GHD in the adult patients had been established at a median age of 8.5 years. Ghrelin was administered at a dose of I μ/kg body weight, i.v. at time zero, and blood for GH determination was obtained at 0, 15, 30, 45, 60, 75, 90, 105 and 120 min. Results: Median GH response after ghrelin was similar between children and adults. Median peak GH response to ghrelin (7.45 μg/l, IQR: 3.9-11.3 mχ/l) was significantly higher in patients with VPS (10.9 μg/l, IQR: 2.4-15.1 μg/l) than in those with PSA (IQR: 2.3-6.7 μg/l; P=0.001). It was significantly higher in subjects with isolated GHD (12.5 μg/l, IQR: 10.8-15.5 μg/1) than in those with multiple pituitary hormone deficiencies (5.15 μg/l, IQR: 2.4-9.0 μg/l; P = 0.003). No correlation was found between the GH peak after ghrelin and body mass index. Conclusion: The GH response to ghrelin in patients with congenital hypopituitarism depends on the degree of the anatomical abnormalities and lends further support to the assumption that the main action of the peptide is exerted at the hypothalamic level and requires the integrity of hypothalamic-pituitary connections.

Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalEuropean Journal of Endocrinology
Volume156
Issue number4
DOIs
Publication statusPublished - Apr 2007

Fingerprint

Ghrelin
Pituitary Gland
Blood Vessels
Pituitary Dwarfism
Hypopituitarism
Pituitary Hormones
Young Adult
Body Mass Index
Body Weight
Magnetic Resonance Imaging
Peptides

ASJC Scopus subject areas

  • Endocrinology

Cite this

GH response to ghrelin in subjects with congenital GH deficiency : Evidence that ghrelin action requires hypothalamic-pituitary connections. / Maghnie, Mohamad; Pennati, Maria Cristina; Civardi, Elisa; Di Iorgi, Natascia; Aimeretti, Gianluca; Foschini, Maria Loreta; Corneli, Ginevra; Tinelli, Carmine; Ghigo, Ezio; Lorini, Renata; Loche, Sandro.

In: European Journal of Endocrinology, Vol. 156, No. 4, 04.2007, p. 449-454.

Research output: Contribution to journalArticle

Maghnie, Mohamad ; Pennati, Maria Cristina ; Civardi, Elisa ; Di Iorgi, Natascia ; Aimeretti, Gianluca ; Foschini, Maria Loreta ; Corneli, Ginevra ; Tinelli, Carmine ; Ghigo, Ezio ; Lorini, Renata ; Loche, Sandro. / GH response to ghrelin in subjects with congenital GH deficiency : Evidence that ghrelin action requires hypothalamic-pituitary connections. In: European Journal of Endocrinology. 2007 ; Vol. 156, No. 4. pp. 449-454.
@article{84fe5006eeb6480790712cb880a7accd,
title = "GH response to ghrelin in subjects with congenital GH deficiency: Evidence that ghrelin action requires hypothalamic-pituitary connections",
abstract = "Objectives: Evaluation of GH response to ghrelin in patients with GH deficiency (GHD) may help to elucidate the site and mechanism of action of ghrelin. We aimed to investigate the GH-releasing effect of ghrelin in children and young adults with childhood-onset GHD. Design: All subjects underwent ghrelin testing and neuro-imaging examination. Magnetic resonance imaging evidenced the presence of a vascular pituitary stalk (VPS) or its complete absence (PSA). Patients and methods: Seventeen prepubertal children and nine adult patients with childhood-onset GHD were selected for the study. The children were enrolled at a median age of 5.8 years. The adult subjects were included at a median age of 23.3 years. The diagnosis of GHD in the adult patients had been established at a median age of 8.5 years. Ghrelin was administered at a dose of I μ/kg body weight, i.v. at time zero, and blood for GH determination was obtained at 0, 15, 30, 45, 60, 75, 90, 105 and 120 min. Results: Median GH response after ghrelin was similar between children and adults. Median peak GH response to ghrelin (7.45 μg/l, IQR: 3.9-11.3 mχ/l) was significantly higher in patients with VPS (10.9 μg/l, IQR: 2.4-15.1 μg/l) than in those with PSA (IQR: 2.3-6.7 μg/l; P=0.001). It was significantly higher in subjects with isolated GHD (12.5 μg/l, IQR: 10.8-15.5 μg/1) than in those with multiple pituitary hormone deficiencies (5.15 μg/l, IQR: 2.4-9.0 μg/l; P = 0.003). No correlation was found between the GH peak after ghrelin and body mass index. Conclusion: The GH response to ghrelin in patients with congenital hypopituitarism depends on the degree of the anatomical abnormalities and lends further support to the assumption that the main action of the peptide is exerted at the hypothalamic level and requires the integrity of hypothalamic-pituitary connections.",
author = "Mohamad Maghnie and Pennati, {Maria Cristina} and Elisa Civardi and {Di Iorgi}, Natascia and Gianluca Aimeretti and Foschini, {Maria Loreta} and Ginevra Corneli and Carmine Tinelli and Ezio Ghigo and Renata Lorini and Sandro Loche",
year = "2007",
month = "4",
doi = "10.1530/EJE-06-0642",
language = "English",
volume = "156",
pages = "449--454",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "4",

}

TY - JOUR

T1 - GH response to ghrelin in subjects with congenital GH deficiency

T2 - Evidence that ghrelin action requires hypothalamic-pituitary connections

AU - Maghnie, Mohamad

AU - Pennati, Maria Cristina

AU - Civardi, Elisa

AU - Di Iorgi, Natascia

AU - Aimeretti, Gianluca

AU - Foschini, Maria Loreta

AU - Corneli, Ginevra

AU - Tinelli, Carmine

AU - Ghigo, Ezio

AU - Lorini, Renata

AU - Loche, Sandro

PY - 2007/4

Y1 - 2007/4

N2 - Objectives: Evaluation of GH response to ghrelin in patients with GH deficiency (GHD) may help to elucidate the site and mechanism of action of ghrelin. We aimed to investigate the GH-releasing effect of ghrelin in children and young adults with childhood-onset GHD. Design: All subjects underwent ghrelin testing and neuro-imaging examination. Magnetic resonance imaging evidenced the presence of a vascular pituitary stalk (VPS) or its complete absence (PSA). Patients and methods: Seventeen prepubertal children and nine adult patients with childhood-onset GHD were selected for the study. The children were enrolled at a median age of 5.8 years. The adult subjects were included at a median age of 23.3 years. The diagnosis of GHD in the adult patients had been established at a median age of 8.5 years. Ghrelin was administered at a dose of I μ/kg body weight, i.v. at time zero, and blood for GH determination was obtained at 0, 15, 30, 45, 60, 75, 90, 105 and 120 min. Results: Median GH response after ghrelin was similar between children and adults. Median peak GH response to ghrelin (7.45 μg/l, IQR: 3.9-11.3 mχ/l) was significantly higher in patients with VPS (10.9 μg/l, IQR: 2.4-15.1 μg/l) than in those with PSA (IQR: 2.3-6.7 μg/l; P=0.001). It was significantly higher in subjects with isolated GHD (12.5 μg/l, IQR: 10.8-15.5 μg/1) than in those with multiple pituitary hormone deficiencies (5.15 μg/l, IQR: 2.4-9.0 μg/l; P = 0.003). No correlation was found between the GH peak after ghrelin and body mass index. Conclusion: The GH response to ghrelin in patients with congenital hypopituitarism depends on the degree of the anatomical abnormalities and lends further support to the assumption that the main action of the peptide is exerted at the hypothalamic level and requires the integrity of hypothalamic-pituitary connections.

AB - Objectives: Evaluation of GH response to ghrelin in patients with GH deficiency (GHD) may help to elucidate the site and mechanism of action of ghrelin. We aimed to investigate the GH-releasing effect of ghrelin in children and young adults with childhood-onset GHD. Design: All subjects underwent ghrelin testing and neuro-imaging examination. Magnetic resonance imaging evidenced the presence of a vascular pituitary stalk (VPS) or its complete absence (PSA). Patients and methods: Seventeen prepubertal children and nine adult patients with childhood-onset GHD were selected for the study. The children were enrolled at a median age of 5.8 years. The adult subjects were included at a median age of 23.3 years. The diagnosis of GHD in the adult patients had been established at a median age of 8.5 years. Ghrelin was administered at a dose of I μ/kg body weight, i.v. at time zero, and blood for GH determination was obtained at 0, 15, 30, 45, 60, 75, 90, 105 and 120 min. Results: Median GH response after ghrelin was similar between children and adults. Median peak GH response to ghrelin (7.45 μg/l, IQR: 3.9-11.3 mχ/l) was significantly higher in patients with VPS (10.9 μg/l, IQR: 2.4-15.1 μg/l) than in those with PSA (IQR: 2.3-6.7 μg/l; P=0.001). It was significantly higher in subjects with isolated GHD (12.5 μg/l, IQR: 10.8-15.5 μg/1) than in those with multiple pituitary hormone deficiencies (5.15 μg/l, IQR: 2.4-9.0 μg/l; P = 0.003). No correlation was found between the GH peak after ghrelin and body mass index. Conclusion: The GH response to ghrelin in patients with congenital hypopituitarism depends on the degree of the anatomical abnormalities and lends further support to the assumption that the main action of the peptide is exerted at the hypothalamic level and requires the integrity of hypothalamic-pituitary connections.

UR - http://www.scopus.com/inward/record.url?scp=34247557437&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247557437&partnerID=8YFLogxK

U2 - 10.1530/EJE-06-0642

DO - 10.1530/EJE-06-0642

M3 - Article

VL - 156

SP - 449

EP - 454

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 4

ER -