GH responsiveness to repeated GHRH or hexarelin administration in normal adults

Alessandro Sartorio, A. Conti, S. Ferrero, A. Spada, G. Faglia

Research output: Contribution to journalArticle

Abstract

GH responses, calculated as the net incremental area under the curve (GH nAUC/h), to two consecutive 1 μg/kg/bw iv GHRH boluses (administered at 0 and 120 min, test a), to one 1 μg/kg bw iv GHRH bolus followed by a 1 μg/kg/bw iv hexarelin bolus (administered at 0 and 120 min, respectively, test b) and to two consecutive 1 μg/kg/bw iv hexarelin boluses (administered at 0 and 120 min, test c) were evaluated in 6 normal adults. The first GHRH injection caused a clear rise in serum GH levels in all subjects (mean GH nAUC/h, test a: 832.1 ±59.4 ng/ml/h, range: 723.7-1074.0 ng/ml/h; test b: 859.2±122.9 ng/ml/h, range 618.0–1422.7 ng/ml/h). Hexarelin administration elicited a marked GH release (test c: 1424±208.2 ng/ml/h, range: 810.0–2154.0 ng/ml/h), which was significantly higher than those observed after GHRH (vs test a: p

Original languageEnglish
Pages (from-to)718-722
Number of pages5
JournalJournal of Endocrinological Investigation
Volume18
Issue number9
DOIs
Publication statusPublished - 1995

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Keywords

  • GH
  • GHRH
  • hexarelin
  • normals

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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