GH-secreting pituitary adenomas: pretreatment with somatostatin analogs plus endoscopic transsphenoidal surgery

P. Cappabianca, A. Alfleri, A. Colao, L. M. Cavallo, P. Marzullo, G. Lombardi, E. De Divitiis

Research output: Contribution to journalArticlepeer-review

Abstract

Among the 66 patients operated by means of an endoscopie endonasal unilateral transsphenoidal approach for sellar lesions, 58 were affected by a pituitary adenoma: 15 of these were GH-secreting, 1 GH-PRL-secreting, l GH-TSH-secreting, 9 were macroadenomas, 4 microadenomas, and 4 recurrent tumours. All the patients underwent preoperative treatment with somatostatin analogs for a three-month period at least. The removal was total in 11 patients, subtotal in 3 and partial in 2 paninvasive tumours. Due to the preexisting sphenoidotomy and thanks to the avoidance of the nasal submucosal phase, treatment of recurrences was safer and quicker. Discharge from the hospital was often possible the day after surgery. The better condition of the patients treated with somatostatin analogs before surgery, the excellent surgical outcome, the short hospital stay and the compliance of the patients lead us to employ this very sequence in subjects with a GH-secreting pituitary tumour, before considering radiotherapy, also in recurrences.

Original languageEnglish
Pages (from-to)8
Number of pages1
JournalSkull Base Surgery
Volume9
Issue numberSUPPL. 2
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Clinical Neurology

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