GH/IGF-I axis in Prader-Willi syndrome: Evaluation of IGF-I levels and of the somatotroph responsiveness to various provocative stimuli

A. Corrias, J. Bellone, L. Beccaria, L. Bosio, G. Trifirò, C. Livieri, L. Ragusa, A. Salvatoni, M. Andreo, P. Ciampalini, G. Tonini, A. Crinò

Research output: Contribution to journalArticle

Abstract

Basal IGF-I levels and the GH response to at least two among provocative stimuli such as clonidine (CLO, Catapresan, 150 mcg/m2 po), GHRH (1 mcg/kg iv)+arginine (ARG, 0.5 g/kg iv infusion during 30 min) and GHRH+pyridostigmine (PD, Mestinon cpr 60 mg po) have been evaluated in 43 children with Prader-Willi syndrome (PWS, 17 males and 26 females, age 3-22 yr, 7 normal weight and 36 obese PWS), in 25 normal short children (NC, 17 males and 8 females, 7.7-18.5 yr) and in 24 children with simple obesity (OB, 14 males, 10 females, 7.7-21.5 yr). Both normal weight and obese PWS had mean IGF-I levels lower than those recorded in NC (p

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalJournal of Endocrinological Investigation
Volume23
Issue number2
Publication statusPublished - 2000

Keywords

  • Arginine
  • Clonidine
  • GH
  • GHRH
  • IGF-I
  • Obesity
  • Prader-Willi syndrome
  • Pryidostigmine

ASJC Scopus subject areas

  • Endocrinology

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    Corrias, A., Bellone, J., Beccaria, L., Bosio, L., Trifirò, G., Livieri, C., Ragusa, L., Salvatoni, A., Andreo, M., Ciampalini, P., Tonini, G., & Crinò, A. (2000). GH/IGF-I axis in Prader-Willi syndrome: Evaluation of IGF-I levels and of the somatotroph responsiveness to various provocative stimuli. Journal of Endocrinological Investigation, 23(2), 84-89.