TY - JOUR
T1 - Ghrelin Derangements in Idiopathic Dilated Cardiomyopathy
T2 - Impact of Myocardial Disease Duration and Left Ventricular Ejection Fraction
AU - Aleksova, Aneta
AU - Beltrami, Antonio Paolo
AU - Bevilacqua, Elisa
AU - Padoan, Laura
AU - Santon, Daniela
AU - Biondi, Federico
AU - Barbati, Giulia
AU - Stenner, Elisabetta
AU - Gortan Cappellari, Gianluca
AU - Barazzoni, Rocco
AU - Ziberna, Fabiana
AU - Zwas, Donna R
AU - Avraham, Yosefa
AU - Agostoni, Piergiuseppe
AU - Not, Tarcisio
AU - Livi, Ugolino
AU - Sinagra, Gianfranco
PY - 2019/8/1
Y1 - 2019/8/1
N2 - BACKGROUND: Ghrelin may exert positive effects on cardiac structure and function in heart failure (HF) patients.METHODS: We assessed ghrelin levels in 266 dilated cardiomyopathy (DCM) patients and in 200 age, gender and body mass index (BMI) matched controls. Further, we evaluated the expression of ghrelin and growth hormone secretagogue-receptor (GHSR) in the myocardium of 41 DCM patients and in 11 controls.RESULTS: DCM patients had significantly lower levels of total, acylated and unacylated ghrelin when compared to controls (p <0.05 for all). In controls, we observed a negative correlation of ghrelin with age, male gender and BMI. These correlations were lost in the DCM group, except for male gender. Total ghrelin was higher in patients with more recent diagnosis when compared to patients with longer duration of the DCM (p = 0.033). Further, total ghrelin was higher in patients with lower left ventricular systolic function (
AB - BACKGROUND: Ghrelin may exert positive effects on cardiac structure and function in heart failure (HF) patients.METHODS: We assessed ghrelin levels in 266 dilated cardiomyopathy (DCM) patients and in 200 age, gender and body mass index (BMI) matched controls. Further, we evaluated the expression of ghrelin and growth hormone secretagogue-receptor (GHSR) in the myocardium of 41 DCM patients and in 11 controls.RESULTS: DCM patients had significantly lower levels of total, acylated and unacylated ghrelin when compared to controls (p <0.05 for all). In controls, we observed a negative correlation of ghrelin with age, male gender and BMI. These correlations were lost in the DCM group, except for male gender. Total ghrelin was higher in patients with more recent diagnosis when compared to patients with longer duration of the DCM (p = 0.033). Further, total ghrelin was higher in patients with lower left ventricular systolic function (
U2 - 10.3390/jcm8081152
DO - 10.3390/jcm8081152
M3 - Article
VL - 8
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
SN - 2077-0383
IS - 8
ER -