Gianotti-Crosti syndrome and allergic background

Giampaolo Ricci, Annalisa Patrizi, Iria Neri, Fernando Specchia, Giulio Tosti, Massimo Masi

Research output: Contribution to journalArticlepeer-review


The aim of the study was to verify whether there is a relationship between Gianotti-Crosti syndrome and an allergic background in children. Twenty-nine children affected by Gianotti-Crosti syndrome were first screened for a large panel of microbiological examinations, including serological and cultural tests for viruses and bacteria. A causative agent was identified in only 10 cases (34.4%). In five cases a diagnosis of Epstein - Barr virus infection was made on the basis of significant titres of anti-Epstein-Barr virus antibodies (IgM) associated with constitutional symptoms (fever, pharyngitis-tonsillitis). Our data concur with several clinical studies demonstrating that Epstein-Barr virus is now the most common viral agent associated with Gianotti-Crosti syndrome. For allergic evaluation, a group of 59 age- and sex-matched children investigated for recurrent infections were used as controls. The presence of atopic dermatitis (24.1%) in those with Gianotti-Crosti syndrome was significantly higher (p

Original languageEnglish
Pages (from-to)202-205
Number of pages4
JournalActa Dermato-Venereologica
Issue number3
Publication statusPublished - 2003


  • Acrodermatitis
  • Allergy
  • Atopic dermatitis
  • Epstein-Barr virus
  • Infantile papular eruption

ASJC Scopus subject areas

  • Dermatology


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