Giant cell myocarditis responding to immunosuppressive therapy

Andrea Frustaci, Cristina Chimenti, Maurizio Pieroni, Nicola Gentiloni

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

An unusual case of giant cell myocarditis presenting with cardiogenic shock that dramatically responded to conventional dose of steroids and azathioprine is reported. Cardiac recovery was rapid, complete (left ventricular ejection fraction rose to 55% from 10%), and was accompanied by the disappearance of the inflammatory infiltrates including giant cells in the control endomyocardial biopsy. Maintenance of the recovery at 16 months of follow-up on a low dose of azathioprine suggests that giant cell myocarditis might be a heterogeneous disease having either a negative untreatable trend necessitating cardiac transplantation, or a curable substrate responding to immunosuppressive drugs.

Original languageEnglish
Pages (from-to)905-907
Number of pages3
JournalChest
Volume117
Issue number3
Publication statusPublished - 2000

Fingerprint

Myocarditis
Giant Cells
Immunosuppressive Agents
Azathioprine
Cardiogenic Shock
Heart Transplantation
Stroke Volume
Therapeutics
Steroids
Maintenance
Biopsy
Pharmaceutical Preparations

Keywords

  • Giant cell myocarditis
  • Heart failure
  • Immunosuppressive therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Giant cell myocarditis responding to immunosuppressive therapy. / Frustaci, Andrea; Chimenti, Cristina; Pieroni, Maurizio; Gentiloni, Nicola.

In: Chest, Vol. 117, No. 3, 2000, p. 905-907.

Research output: Contribution to journalArticle

Frustaci, A, Chimenti, C, Pieroni, M & Gentiloni, N 2000, 'Giant cell myocarditis responding to immunosuppressive therapy', Chest, vol. 117, no. 3, pp. 905-907.
Frustaci, Andrea ; Chimenti, Cristina ; Pieroni, Maurizio ; Gentiloni, Nicola. / Giant cell myocarditis responding to immunosuppressive therapy. In: Chest. 2000 ; Vol. 117, No. 3. pp. 905-907.
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