TY - JOUR
T1 - Giant cell tumor of the extremity
T2 - A review of 349 cases from a single institution
AU - Errani, Costantino
AU - Ruggieri, Pietro
AU - Asenzio, Marco Antonio Nogales
AU - Toscano, Angelo
AU - Colangeli, Simone
AU - Rimondi, Eugenio
AU - Rossi, Giuseppe
AU - Longhi, Alessandra
AU - Mercuri, Mario
PY - 2010/2
Y1 - 2010/2
N2 - Giant cell tumor is still one of the most controversial and discussed bone tumors. Surgical treatment options include intralesional excision or segmental resection. Curettage has a higher recurrence rate but does preserve adjacent joint function. After curettage, the use of adjuvant therapies is still controversial. Three hundred forty-nine patients with giant cell tumors of the extremity, treated in a single institution, were analyzed in a retrospective study. Two hundred patients underwent curettage of the lesion and in 64 of these cases, three local adjuvants, such as phenol, alcohol and cement, were employed. The hypothesis is that an "aggressive curettage" with phenol, alcohol and cement provides better local control and functional results. The correlation between tumor in the proximal femur and higher recurrence rate has not been recorded before. The results of the present study suggest that an "aggressive curettage" reduces the recurrence rate in a disease whose aggressiveness is not easy to predict. Special attention must be given to giant cell tumors not only in the distal radius, but also in the proximal femur, where the treatment is more difficult and associated with a higher rate of local recurrence. Crown
AB - Giant cell tumor is still one of the most controversial and discussed bone tumors. Surgical treatment options include intralesional excision or segmental resection. Curettage has a higher recurrence rate but does preserve adjacent joint function. After curettage, the use of adjuvant therapies is still controversial. Three hundred forty-nine patients with giant cell tumors of the extremity, treated in a single institution, were analyzed in a retrospective study. Two hundred patients underwent curettage of the lesion and in 64 of these cases, three local adjuvants, such as phenol, alcohol and cement, were employed. The hypothesis is that an "aggressive curettage" with phenol, alcohol and cement provides better local control and functional results. The correlation between tumor in the proximal femur and higher recurrence rate has not been recorded before. The results of the present study suggest that an "aggressive curettage" reduces the recurrence rate in a disease whose aggressiveness is not easy to predict. Special attention must be given to giant cell tumors not only in the distal radius, but also in the proximal femur, where the treatment is more difficult and associated with a higher rate of local recurrence. Crown
KW - Bone tumor
KW - Curettage
KW - Extremity
KW - Giant cell tumor
KW - Resection
KW - Surgery
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U2 - 10.1016/j.ctrv.2009.09.002
DO - 10.1016/j.ctrv.2009.09.002
M3 - Article
C2 - 19879054
AN - SCOPUS:74649085010
VL - 36
SP - 1
EP - 7
JO - Cancer Treatment Reviews
JF - Cancer Treatment Reviews
SN - 0305-7372
IS - 1
ER -