Giant nevus represents a peculiar type of congenital nevus commonly involving extensive body areas. Histogenetically, it is considered a hamartoma deriving from the neural crest. Specific histologic features allow the distinction between the congenital form and the acquired counterpart. The giant type of congenital melanocytic nevus shows melanocytes extending into the subcutaneous fat. From the ultrastructural point of view, the nevus cells show tight relations with collagen and elastic fibers of the reticular dermis. According to literature malignant transformation has been considered a possibility in various percentages of observed patients. This variability may be also due to the presence of histologic aspects of congenital nevi simulating 'in situ' melanoma.
|Translated title of the contribution||Giant congenital melanocytic nevus|
|Number of pages||10|
|Journal||Rivista Italiana di Chirurgia Plastica|
|Publication status||Published - 1991|
ASJC Scopus subject areas