Giant Hepatic Hemangioma and Placental Chorangiosis: A Unique Case of Stillbirth?

Michele Paudice, Leonardo Alett Peñuela, Flaminia Torielli, Bruno Spina, Valentino Remorgida, Francesca Buffelli, Ezio Fulcheri, Cesare Arioni, Valerio Gaetano Vellone

Research output: Contribution to journalArticlepeer-review


INTRODUCTION: Hepatic hemangiomas (HH) are benign vascular tumors, and when large, may contribute to fetal morbidity/mortality. Chorangiosis is placental villus capillary hypervascularity, probably linked with fetal hypoxia.

CASE REPORT: We present a macrosomic stillbirth at 39 + 3 weeks of gestation with congestive heart failure (CHF) and myocardial infarction. A giant right hepatic lobe HH was present, along with placental chorangiosis.

CONCLUSION: A common pathogenetic pathway between congenital HH and placental chorangiosis has not been reported. Our case suggests that the effects of HH and chorangiosis increase the risk of late fetal loss due to the high-output CHF.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalFetal and Pediatric Pathology
Issue number2
Publication statusPublished - Apr 2019


  • Adult
  • Chorionic Villi/pathology
  • Female
  • Hemangioma/diagnosis
  • Hemangioma, Cavernous/diagnosis
  • Humans
  • Liver/pathology
  • Liver Neoplasms/diagnosis
  • Placenta/pathology
  • Placenta Diseases/diagnosis
  • Pregnancy
  • Stillbirth/genetics


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