Giant merkel cell carcinoma of the lower limb: Case report and review of the literature

Andrea Marchesi, Pier Camillo Parodi, Marco Brioschi, Giorgio Sileo, Matteo Marchesi, Luca Vaienti

Research output: Contribution to journalArticle

Abstract

Background: Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy that usually grows rapidly at the head and neck. Giant forms at the lower limbs are rarely reported and usually affect patients in the eighth decade or older. Methods: We report the case of a 60-year-old man who presented with a giant MCC on his right thigh. We managed this case by applying the 2012 updated guidelines and reviewed all cases of giant MCC of the lower limbs reported in the literature. Results: At the 4-month follow-up, the patient showed complete remission. Conclusion: Giant forms of MCC are still treated as typical cases of MCC, when these patients show a very poor prognosis. In young and adult people, such as our case, wide surgical excisions, sentinel lymph node biopsy in clinically negative node cases, radiotherapy of the regional drain area, and a strict follow-up should be routinely performed to improve patients' survival.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalJournal of Cutaneous Medicine and Surgery
Volume17
Issue number5
DOIs
Publication statusPublished - Sep 2013

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Giant Cell Carcinoma
Merkel Cell Carcinoma
Lower Extremity
Sentinel Lymph Node Biopsy
Thigh
Young Adult
Neck
Radiotherapy
Head
Guidelines
Skin
Survival
Neoplasms

ASJC Scopus subject areas

  • Dermatology
  • Surgery
  • Medicine(all)

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Giant merkel cell carcinoma of the lower limb : Case report and review of the literature. / Marchesi, Andrea; Parodi, Pier Camillo; Brioschi, Marco; Sileo, Giorgio; Marchesi, Matteo; Vaienti, Luca.

In: Journal of Cutaneous Medicine and Surgery, Vol. 17, No. 5, 09.2013, p. 351-355.

Research output: Contribution to journalArticle

Marchesi, A, Parodi, PC, Brioschi, M, Sileo, G, Marchesi, M & Vaienti, L 2013, 'Giant merkel cell carcinoma of the lower limb: Case report and review of the literature', Journal of Cutaneous Medicine and Surgery, vol. 17, no. 5, pp. 351-355. https://doi.org/10.2310/7750.2013.12121
Marchesi, Andrea ; Parodi, Pier Camillo ; Brioschi, Marco ; Sileo, Giorgio ; Marchesi, Matteo ; Vaienti, Luca. / Giant merkel cell carcinoma of the lower limb : Case report and review of the literature. In: Journal of Cutaneous Medicine and Surgery. 2013 ; Vol. 17, No. 5. pp. 351-355.
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