Giant subcortical heterotopia involving the temporo-parieto-occipital region: A challenging cause of drug-resistant epilepsy

Federica Novegno, Domenica Battaglia, Daniela Chieffo, Paolo Frassanito, Chiara Leoni, Gianpiero Tamburrini, Luca Massimi, Tommaso Tartaglione, Concezio Di Rocco, Francesco Guzzetta

Research output: Contribution to journalArticle

Abstract

The clinical, radiological, neurophysiological and neuropsychological findings of three patients with giant subcortical heterotopia are reported. All patients experienced psychomotor and behaviour improvement after surgery. Two subjects are seizure-free after complete excision of the heterotopia; the third patient significantly improved following subtotal removal (Engel's class II). Patients affected by giant subcortical heterotopias can have a favourable prognosis after the surgical removal of the malformation, even following long-lasting epilepsy.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalEpilepsy Research
Volume87
Issue number1
DOIs
Publication statusPublished - Nov 2009

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Keywords

  • Cognitive delay
  • Drug-resistant epilepsy
  • Infancy
  • Subcortical heterotopia
  • Surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Novegno, F., Battaglia, D., Chieffo, D., Frassanito, P., Leoni, C., Tamburrini, G., Massimi, L., Tartaglione, T., Di Rocco, C., & Guzzetta, F. (2009). Giant subcortical heterotopia involving the temporo-parieto-occipital region: A challenging cause of drug-resistant epilepsy. Epilepsy Research, 87(1), 88-94. https://doi.org/10.1016/j.eplepsyres.2009.06.006