Ginkgolic acid protects against Aβ-induced synaptic dysfunction in the hippocampus

Dalila Mango, Filippo Weisz, Robert Nisticò

Research output: Contribution to journalArticle

Abstract

Ginkgo leaf is the most used form of supplement for cognitive ailments. The standardized extract formulation EGb 761 is a dietary supplement with proven benefit in several neurological and psychiatric conditions including memory decline in Alzheimer's disease, schizophrenia and dementia. Ginkgolic acid (GA) is a component of this extract which shows pleiotropic effects including antitumoral and anti-HIV action; however, its effect on memory is still unknown. Here, we carried out an electrophysiological analysis to investigate the effects of GA on long term potentiation and synaptic transmission at CA1 hippocampal synapses. We also evaluated the potential rescuing effect of GA on the synaptic dysfunction following in vitro application of Aβ. Data obtained indicate that GA exerts neuroprotective effects against Aβ-induced impairment of neurotransmitter release and synaptic plasticity.

Original languageEnglish
Article number401
JournalFrontiers in Pharmacology
Volume7
Issue numberOCT
DOIs
Publication statusPublished - Oct 26 2016
Externally publishedYes

Keywords

  • Electrophysiology
  • Ginkgolic acid
  • Hippocampus
  • LTP

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Ginkgolic acid protects against Aβ-induced synaptic dysfunction in the hippocampus'. Together they form a unique fingerprint.

  • Cite this