TY - JOUR
T1 - Glandular odontogenic cyst
T2 - Review of literature and report of a new case with cytokeratin-19 expression
AU - Mascitti, Marco
AU - Santarelli, Andrea
AU - Sabatucci, Antonio
AU - Procaccini, Maurizio
AU - Muzio, Lorenzo Lo
AU - Zizzi, Antonio
AU - Rubini, Corrado
PY - 2014
Y1 - 2014
N2 - The glandular odontogenic cyst (GOC) was a rare jawbone cyst described in 1988 as a distinct entity. This lesion can involve either jaw, and the anterior region of the mandible was the most commonly affected area. Clinical and radiographic findings were not specific, and the diagnosis of GOC can be extremely difficult due to the rarity of this lesion. The cyst presented a wall constituted by fibrous connective tissue and was lined by a non-keratinized stratified squamous epithelium of variable thickness. Large areas of the lining epithelium presented cylinder cells, sometimes ciliated. A variable amount of mucina was occasionally noted. Due to the strong similarities, this cyst can be easily misdiag nosed as a central mucoepidermoid carcinoma (CMEC). Immunohistochemistry may be an aid in diagnosis; in fact has been demonstrated that there were differences in the expression of cytokeratins (CK) in GOC and CMEC. In this study, we reported a new case of GOC in a 38 year female patient. In addition, we carried out a review of 110 previous cases reported in literature.
AB - The glandular odontogenic cyst (GOC) was a rare jawbone cyst described in 1988 as a distinct entity. This lesion can involve either jaw, and the anterior region of the mandible was the most commonly affected area. Clinical and radiographic findings were not specific, and the diagnosis of GOC can be extremely difficult due to the rarity of this lesion. The cyst presented a wall constituted by fibrous connective tissue and was lined by a non-keratinized stratified squamous epithelium of variable thickness. Large areas of the lining epithelium presented cylinder cells, sometimes ciliated. A variable amount of mucina was occasionally noted. Due to the strong similarities, this cyst can be easily misdiag nosed as a central mucoepidermoid carcinoma (CMEC). Immunohistochemistry may be an aid in diagnosis; in fact has been demonstrated that there were differences in the expression of cytokeratins (CK) in GOC and CMEC. In this study, we reported a new case of GOC in a 38 year female patient. In addition, we carried out a review of 110 previous cases reported in literature.
KW - Cytokeratins
KW - Glandular odontogenic cyst
KW - Odontogenic cyst
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U2 - 10.2174/1874210601408010001
DO - 10.2174/1874210601408010001
M3 - Article
AN - SCOPUS:84897832894
VL - 8
SP - 1
EP - 12
JO - Open Dentistry Journal
JF - Open Dentistry Journal
SN - 1874-2106
IS - 1
ER -