Glandular odontogenic cyst: Review of literature and report of a new case with cytokeratin-19 expression

Marco Mascitti, Andrea Santarelli, Antonio Sabatucci, Maurizio Procaccini, Lorenzo Lo Muzio, Antonio Zizzi, Corrado Rubini

Research output: Contribution to journalArticle

Abstract

The glandular odontogenic cyst (GOC) was a rare jawbone cyst described in 1988 as a distinct entity. This lesion can involve either jaw, and the anterior region of the mandible was the most commonly affected area. Clinical and radiographic findings were not specific, and the diagnosis of GOC can be extremely difficult due to the rarity of this lesion. The cyst presented a wall constituted by fibrous connective tissue and was lined by a non-keratinized stratified squamous epithelium of variable thickness. Large areas of the lining epithelium presented cylinder cells, sometimes ciliated. A variable amount of mucina was occasionally noted. Due to the strong similarities, this cyst can be easily misdiag nosed as a central mucoepidermoid carcinoma (CMEC). Immunohistochemistry may be an aid in diagnosis; in fact has been demonstrated that there were differences in the expression of cytokeratins (CK) in GOC and CMEC. In this study, we reported a new case of GOC in a 38 year female patient. In addition, we carried out a review of 110 previous cases reported in literature.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalOpen Dentistry Journal
Volume8
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Cytokeratins
  • Glandular odontogenic cyst
  • Odontogenic cyst

ASJC Scopus subject areas

  • Dentistry(all)

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