Glass capillary gas chromatographic determination of Nτ-methylhistidine in urine

L. Cotellessa, F. Marcucci, D. Cani, P. Sfondrini, L. Colombo, E. Mussini

Research output: Chapter in Book/Report/Conference proceedingChapter


This paper describes a method for the isolation from biological specimens and quantitative determination of His( (τMe) by glass capillary gas chromatography (GC). The present method, with a sensitivity of 5 ng/μl, appears to be reliable for determining His( (τMe) in urine of animals and man in normal and pathological conditions. The use of an ECD increases the sensitivity about 100-fold, thus making it suitable for measuring very low His( (τMe) levels, in studies of the catabolic rates of muscle proteins, for instance.

Original languageEnglish
Title of host publicationJournal of Chromatography
Number of pages6
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine


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