Glatiramer acetate

Research output: Contribution to journalArticle

Abstract

Glatiramer acetate (GA) is a mixture of synthetic polypeptides composed of four aminoacids. GA is very effective in suppression of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). Various mechanisms of action of GA have been proposed, but the most important is probably the induction of antigen-specific suppressor T cells. Class one clinical trials have demonstrated that GA reduces the relapse rate and the accumulation of disability in relapsing-remitting (RR) MS. The positive effects on disease activity and disease progression are explained by the reduction of the number and volume of the active lesions as showed by Magnetic resonance imaging (MRI) studies. Moreover new MRI techniques suggest that GA may also have some neuroprotective effects. The drug is usually well tolerated with modest side effects. In vitro and in vivo animal studies have shown that GA is devoid of teratogenic or mutagenic effects. GA is a good alternative to interferon beta for treatment of RR-MS.

Original languageEnglish
Pages (from-to)244-258
Number of pages15
JournalNeurologia
Volume17
Issue number5
Publication statusPublished - May 2002

Keywords

  • Disability
  • Experimental autoimmune encephalomyelitis
  • Glatiramer acetate
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Relapsing-remitting
  • Side effects
  • Th1/Th2 cells

ASJC Scopus subject areas

  • Clinical Neurology

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